急性胰腺炎患者血浆丙二醛、C反应蛋白和内皮素水平与肠粘膜屏障功能的相关性研究  

A Correlative Study of Malondialdehyde,C-reactive-protein and Endothelin Level to Intestinal Mucosal Barrier Function in Cases with Acute Pancreatitis

作　　者：韩小勇 陈勇 张洁 戴晓林 Han Xiaoyong;Chen Yong;Zhang Jie;Dai Xiaolin(Department of Gastroenterology,the People's Hospital of Wanzhou District,Chongqing,404000,P.R.China)

机构地区：[1]重庆市万州区人民医院消化科

出　　处：《西南军医》2019年第5期401-402,共2页Journal of Military Surgeon in Southwest China

基　　金：重庆市万州区科委立项课题(编号:201403037)

摘　　要：目的探讨急性胰腺炎患者血浆丙二醛(MDA)、C反应蛋白(CRP)和内皮素(ET)水平与肠粘膜屏障功能的关系。方法将120例确诊AP患者分为SAP52例,MAP68例,检测入院时、72小时MDA、CRP、ET和尿L/M值,并比较和APACHE-Ⅱ评分的关系。结果两组患者MDA、ET、CRP和L/M均有不同程度增高,MAP组CRP和L/M在72小时高于入院时(P<0.05),SAP组的四个指标72小时明显高于入院时(P<0.05)。结论血浆MDA、ET和CRP与APACHE-Ⅱ评分和肠道粘膜屏障功能有很好的相关性,可作为评估病情的指标。Objective To discuss the relationship of malondialdehyde(MDA),C-reactive protein(CRP) and endothelin(ET) in blood plasma with intestinal mucosal barrier function in cases with acute pancreatitis(AP). Methods120 cases with confirmed diagnosis of AP were enrolled,including 52 cases with severe AP(SAP group) and 68 cases with mild AP(MAP group);the levels of MDA,CRP,ET and the ratio of Lactulose/Mannitol(L/M) were detected at admission and 72 hours after admission,and the results were comparatively studied with APACHE Ⅱ scores. Results The values of MDA,CRP,ET and L/M in both groups increased at a certain degree while the values of CRP and L/M in MAP group 72 hours after admission were higher than those at admission(P<0. 05) and the 4 values in SAP 72 hours after admission were obviously higher than those at admission(P<0. 05). Conclusions MAD,ET,CRP in blood plasma and APACHE Ⅱ scores are in good correlation to intestinal mucosal barrier function,they can be taken as the indicators for disease assessment.

关 键 词：急性胰腺炎 丙二醛 内皮素 C反应蛋白 肠道粘膜屏障功能 

分 类 号：R576[医药卫生—消化系统] R574.4[医药卫生—内科学]