WNT1、β-catenin、PD-L1蛋白在上皮性卵巢浆液性癌中的表达及临床意义  

Expression of WNT1, β-catenin and PD-L1 in patients with epithelial ovarian serous carcinoma and their clinical significance

作　　者：杨尊敬 杜先玲 YANG Zunjing;DU Xianling(Department of Oncology,the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture,Enshi 445000,Hubei,China)

机构地区：[1]恩施自治州中心医院肿瘤科

出　　处：《癌症进展》2019年第17期2079-2082,共4页Oncology Progress

摘　　要：目的探讨无翅型MMTV整合位点家族成员1(WNT1)、β-联蛋白(β-catenin)、程序性死亡受体配体1(PD-L1)表达水平与上皮性卵巢浆液性癌患者的关系。方法选取200例上皮性卵巢浆液性癌患者的卵巢浆液性癌组织和120例因子宫肌瘤行子宫及附件切除术患者的正常卵巢组织。比较两种组织中WNT1、β-catenin、PD-L1蛋白的表达情况,并对WNT1、β-catenin、PD-L1蛋白表达与上皮性卵巢浆液性癌患者临床特征的关系进行分析。结果卵巢浆液性癌组织中WNT1、β-catenin、PD-L1蛋白的阳性表达率均明显高于正常卵巢组织(P﹤0.01)。国际妇产科联盟(FIGO)分期为Ⅲ~Ⅳ期上皮性卵巢浆液性癌患者卵巢浆液性癌组织中WNT1、β-catenin、PD-L1蛋白的阳性表达率均高于FIGO分期为Ⅰ~Ⅱ期的患者(P﹤0.05)。不同分化程度上皮性卵巢浆液性癌患者卵巢浆液性癌组织中WNT1、β-catenin、PD-L1蛋白的阳性表达率比较,差异均无统计学意义(P﹥0.05)。结论WNT1、β-catenin、PD-L1蛋白表达异常可能参与了上皮性卵巢浆液性癌的发生,且其表达水平与上皮性卵巢浆液性癌患者的FIGO分期密切相关。Objective To investigate the relationship between the expression level of wingless-type MMTV integration site family,member 1(WNT1),β-catenin and programmed cell death 1 ligand 1(PD-L1)and the epithelial ovarian serous carcinoma.Method Ovarian serous carcinoma tissues were taken from 200 patients with epithelial ovarian serous carcinoma,and the normal ovarian tissues were taken from 120 patients with uterine fibroids who underwent uterine and accessory resection.The expression of WNT1,β-catenin and PD-L1 were compared in the two groups,and the relationship between WNT1,β-catenin and PD-L1 and clinical characteristics of patients with epithelial ovarian serous carcinoma was analyzed.Result The positive expression rate of WNT1,β-catenin and PD-L1 proteins in ovarian serous carcinoma tissues were significantly higher than those in normal ovarian tissues(P<0.01).The positive expression rate of WNT1,β-catenin and PD-L1 proteins in the ovarian serous carcinoma tissues from patients suffering epithelial ovarian serous carcinoma whose International Federation of Gynecology and Obstetrics(FIGO)stage wasⅢ-Ⅳwere significantly higher than those samples from patients whose FIGO stage wasⅠ-Ⅱ(P<0.05);the positive expression rate of WNT1,β-catenin and PD-L1 proteins in the ovarian serous carcinoma tissues from patients suffering epithelial ovarian serous carcinoma with different differentiation levels did not show statistical significance(P>0.05).Conclusion The aberrant expression level of WNT1,β-catenin and PD-L1 protein may be involved in the initial of ovarian cancer,and have an association with the FIGO stage of ovarian cancer.

关 键 词：卵巢浆液性癌 WNT1蛋白 Β-CATENIN蛋白 PD-L1蛋白 免疫组织化学 

分 类 号：R737.11[医药卫生—肿瘤]