动脉粥样硬化性脑梗死危险因素与平均血小板体积的相关性分析  

Correlation between risk factors of atherosclerotic cerebral infarction and mean platelet volume

作　　者：梅育嘉[1] 罗杰峰[1] 胡瑞婷[2] MEI Yujia;LUO Jiefeng;HU Ruiting(Department of Neurology,the Second Affiliated Hospital of Guangxi Medical University,Nanning 530007,China;Department of Neurology,Minzu Hospital of Guangxi Zhuang Autonomous Region,Nanning 530001,China)

机构地区：[1]广西医科大学第二附属医院神经内科,南宁市530007 [2]广西壮族自治区民族医院神经内科,南宁市530000

出　　处：《微创医学》2019年第4期415-418,425,共5页Journal of Minimally Invasive Medicine

基　　金：广西壮族自治区卫生和计划生育委员会自筹经费科研课题(编号:Z20170092)

摘　　要：目的研究动脉粥样硬化性脑梗死(ACI)患者各危险因素与平均血小板体积(MPV)的因果关系,判断MPV增大是否为ACI的独立危险因素。方法选取确诊为ACI的300例患者为观察对象,记录其MPV等临床信息,按照时间分组行多因素分析及格兰杰因果关系分析,判断与MPV相关的ACI危险因素及其因果关系。结果多因素分析发现,与MPV显著相关(P<0.05)的因素有:血小板计数(PC)、OCSP分型4型(腔隙性脑梗死)、脑白质疏松、白细胞(WBC)计数。对定量指标MPV、WBC、PC进行格兰杰因果关系分析:PC是MPV改变的格兰杰原因;WBC增高对MPV的改变有较强预测作用,可能是MPV改变的格兰杰原因。结论MPV的改变是动脉粥样硬化血栓形成等多因素共同作用的结果,尚无证据证明血小板活化MPV改变是ACI的独立危险因素。Objective To study the causality between risk factors for patients with atherosclerotic cerebral infarction(ACI)and mean platelet volume(MPV),and to determine whether MPV enlargement is an independent risk factor for ACI.Methods A total of 300 patients diagnosed with ACI were selected as observation subjects,and their clinical information on MPV were recorded.Multivariate analysis and Granger causality analysis were conducted in groups by time,and MPV-related risk factors for ACI and their causality were determined.Results Multivariate analysis revealed that the factors significantly associated with MPV(P<0.05)were as follows:platelet count(PC),Oxfordshire Community Stroke Project(OCSP)type 4(lacunar infarction),leukoaraiosis and white blood cell(WBC)count.Granger causality analysis of quantitative indicators,including MPV,WBC count and PC,was performed,and PC was the Granger cause of MPV variance;WBC count had a relatively strong predictive effect on MPV variance,which might be the Granger cause.Conclusion MPV variance results from the combined action of multiple factors such as atherosclerotic thrombosis.There is still no sufficient evidence provided to prove that MPV variance in platelet activation is an independent risk factor for ACI.

关 键 词：动脉粥样硬化 脑梗死 平均血小板体积 格兰杰因果分析 

分 类 号：R743[医药卫生—神经病学与精神病学]