中医辨证维持疗法对晚期非小细胞肺癌生存质量及生存期的影响  

Influence of TCM dialectical maintenance therapy on the living quality and life span in advanced NSCLC patients

作　　者：柳雯[1] 周兰[1] 杨小迪 LIU Wen;ZHOU Lan;YANG XIAO-di(Department of Traditional Chinese Medicine,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004;School of Basic Medicine,Bengbu Medical College,Bengbu Anhui 233000,China)

机构地区：[1]蚌埠医学院第一附属医院中医科,安徽蚌埠233004 [2]蚌埠医学院基础医学院,安徽蚌埠233030

出　　处：《蚌埠医学院学报》2019年第6期712-716,共5页Journal of Bengbu Medical College

基　　金：安徽省高校科研创新平台团队项目(2016-40);安徽省“十三五”省级中医重点专科建设基金(中医药服务秘[2017]567号);蚌埠医学院自然科学研究项目(BYKY1792)

摘　　要：目的:观察一线化疗后中医辨证维持疗法对晚期非小细胞肺癌(NSCLC)生存质量及生存期的影响。方法:将125例经标准一线化疗后取得缓解或稳定的晚期NSCLC病人,随机分为观察组62例和对照组63例,对照组予西医常规对症治疗,观察组在对照组基础上加用规范化中医辨证治疗,2组均治疗至疾病进展或不耐受,比较2组病人生存质量评分、中医证候评分变化,比较2组无进展生存期、总生存期情况。结果:试验结束剔除脱落病例,共纳入统计122例,其中观察组60例,对照组62例。治疗后,观察组卡氏评分和中医证候评分有效率较对照组均提高(P<0.05和P<0.01);生理状况、功能状况、附加情况评分均明显提高(P<0.01),社会或家庭状况、情感状况评分差异均无统计学意义(P>0.05);观察组中位无进展生存期13.90个月,大于对照组的11.30个月(P<0.05),观察组中位总生存期28.90个月,与对照组的16.90个月比较差异无统计学意义(P>0.05)。结论:中医辨证维持疗法应用于晚期NSCLC病人,可改善中医临床症状,提高生存质量,延长无进展生存期。Objective:To observe the effects of Traditional Chinese Medicine(TCM)dialectical maintenance therapy on the living quality and life span in advanced non-small-cell lung cancer(NSCLC)patients after first-line chemotherapy.Methods:One hundred and twenty-five mitigatory or stable advanced NSCLC patients after standard first-line chemotherapy were randomly divided into the observation group(62 cases)and control group(63 cases).The control group received conventional symptomatic treatment with western medicine,and the observation group was treated with TCM dialectical maintenance therapy based on the control group.Two groups were treated to disease progression or intolerance.The scores of survival quality and TCM symptoms,progression-free survival(PFS)and overall survival(OS)were compared between two groups.Results:At the end of the experiment,60 cases in observation group and 62 cases in control group were investigated.Compared with the control group,the scores of TCM symptoms and KPS scores were significantly improved(P<0.05 and P<0.01),and the scores of physiological,functional and additional status were also significantly improved in observation group after treatment(P<0.01).The differences of the scores of emotional,social or family status between two groups after treatment were not statistically significant(P>0.05).The median PFS in observation group(13.90 months)was greater than that in control group(11.30 months)(P<0.05).The median OS in observation group and control group were 28.90 months and 16.90 months,respectively,and the difference of which was not statistically significant(P>0.05).Conclusions:The TCM dialectical maintenance therapy in treating NSCLC can improve the clinical symptoms of TCM and quality of life,and prolong the PFS of patients.

关 键 词：非小细胞肺癌 中医辨证 生存质量 生存期 

分 类 号：R734.2[医药卫生—肿瘤]