强肝丸对肝纤维化患者血清TIMP-1、TIMP-2表达水平的影响  

The effects of oral Qianggan pills on serum expressions of TIMP-1 and TIMP-2 in HBV-infected patients with liver fibrosis

作　　者：赵西太 聂青和 邵彬[2] 龙振昼 高禄化 王媛媛 ZHAO Xitai;NIE Qinghe;SHAO Bin;LONG Zhenzhou;GAO Luhua;WANG Yuanyuan(Department of Infectious Diseases, Chinese PLA Center of Diagnosis and Treatment for Infectious Diseases, Tangdu Hospital, Air Force Medical University, Xi’an 710038;Department of Emergency, Shaanxi Armed Police Hospital, China)

机构地区：[1]空军军医大学唐都医院传染病科/全军感染病诊疗中心,陕西西安710038 [2]武警陕西总队医院急诊科

出　　处：《胃肠病学和肝病学杂志》2019年第9期995-998,共4页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家“十三五”科技重大专项课题(2013ZX10002004);第四军医大学科技发展基金(2017XC052)

摘　　要：目的观察强肝丸对肝纤维化患者血清TIMP-1、TIMP-2表达水平的影响,并探讨其抗肝纤维化的分子机制。方法纳入2016年8月至2018年6月就诊于空军军医大学唐都医院传染病科的慢性乙型肝炎合并肝纤维化的患者228例,随机分为强肝丸组(A组,n=114)和对照组(B组,n=114),两组患者抗病毒治疗不改变,A组同时服用强肝丸。入组时及6个月后分别采取外周血5 ml用于TIMP-1、TIMP-2检测。结果治疗前A组、B组患者血清TIMP-1、TIMP-2的表达水平分别为(428±180)ng/ml、(429±168)ng/ml,(132±48)ng/ml、(136±43)ng/ml,两组间比较差异无统计学意义(P>0.05);治疗6个月后下降为(351±157)ng/ml、(402±173)ng/ml,(112±37.2)ng/ml、(129±44)ng/ml;治疗后两组间TIMP-1、TIMP-2比较,差异有统计学意义,治疗前后相比,A组TIMP-1、TIMP-2差异有统计学意义(P<0.05),而B组的TIMP-1、TIMP-2差异无统计学意义(P>0.05)。结论强肝丸可显著降低肝纤维化患者血清TIMP-1、TIMP-2水平,该效应与其抗肝纤维化的分子机制相关,且具有减轻肝脏炎症的作用。Objective To observe the effects of Qianggan pills on serum expressions of TIMP-1, TIMP-2, and to investigate its molecular mechanism of alleviating liver fibrosis. Methods 228 patients with chronic hepatitis B and liver fibrosis were enrolled from Aug. 2016 to Jun. 2018, in the Department of Infectious Diseases, Tangdu Hospital, Air Force Medical University. The patients were divided randomly into receive nucleos(t)ide analogues(NAs) plus Qianggan pills(group A, 114 cases) or NAs(group B, 114 cases). The levels of serum TIMP-1 and TIMP-2 were measured at baseline and again 6 months later. Results The baseline levels of TIMP-1 and TIMP-2 in serum were similar between group A and group B [(428±180) ng/ml vs(429±168) ng/ml, P=0.960;(132±48) ng/ml vs(136±43) ng/ml, P=0.985]. The serum levels of TIMP-1 and TIMP-2 in group A were significantly dropped to(351±157) ng/ml and(402±173) ng/ml, respectively, after 6 months of therapy. The declines of TIMP-1 and TIMP-2 levels were not statistically significant [(112±37.2) ng/ml,(129±44) ng/ml, respectively]. Conclusion Qianggan pills can lead to reductions of serum TIMP-1 and TIMP-2. The roles of Qianggan pills in repression of TIMP-1 and TIMP-2 are related to the molecular mechanism of liver fibrosis and amelioration of liver inflammation.

关 键 词：强肝丸 肝纤维化 金属蛋白酶组织抑制因子-1 2 酶联免疫吸附测定 分子机制 

分 类 号：R575.2[医药卫生—消化系统]