慢性萎缩性胃炎及胃癌前病变大鼠造模方法的文献研究  

Literature study on the modeling of chronic atrophic gastritis and precancerous lesions in rats

作　　者：陈泽慧[1] 魏玥 安静 彭继升 黄大未[3] 贾云飞 杨晋翔 CHEN Zehui;WEI Yue;AN Jing;PENG Jisheng;HUANG Dawei;JIA Yunfei;YANG Jinxiang(Beijing University of Chinese Medicine,Beijing 100029,China;Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029,China;Zhejiang Traditional Chinese Medicine Hospital,Hangzhou 310006,China;Henan Traditional Chinese Medicine Hospital,Zhengzhou 450002,China)

机构地区：[1]北京中医药大学,北京100029 [2]北京中医药大学第三附属医院,北京100029 [3]浙江省中医院,杭州310006 [4]河南省中医院,郑州450002

出　　处：《天津中医药》2019年第9期850-855,共6页Tianjin Journal of Traditional Chinese Medicine

基　　金：北京中医药大学基本科研业务在读研究生项目(2018-JYBZZ-XS232);国家自然科学基金面上项目(81173232)

摘　　要：[目的]通过对相关文献的整理,把握现阶段慢性萎缩性胃炎(CAG)及胃癌前病变(PLGC)大鼠造模方法研究现状,为进一步完善该病的动物模型制备提供有益指导。[方法]全面检索中国期刊全文数据库(CNKI)、维普中文期刊数据库(VIP)及万方数据库自建库至2018年7月31日关于慢性萎缩性胃炎及胃癌前病变大鼠实验研究,纳入相关文献进行分析。[结果]最终纳入的140篇文献涉及153种造模方法,造模实验动物以雄性、4~6周龄大鼠为主;造模方法多见于复合因素造模,N-甲基-N’-硝基-N-亚硝基胍(MNNG)为主要造模药物;在造模周期方面,单因素与复合因素造模的平均周期不具有统计学差异。[结论] CAG模型的建立具有较长周期、较高死亡率的特点,建立稳定、理想的实验动物模型仍需更深入地探索。[Objective] Through the collation of related literatures,to study the current status of the modeling methods of chronic atrophic gastritis(CAG) and precancerous lesions(PLGC) in rats,and to provide useful guidance for further improving the animal model of this disease.[Methods] A comprehensive search of CNKI,VIP and Wanfang Database Self-built Library to July 31,2018 on experimental study of chronic atrophic gastritis and precancerous lesions in rats, including relevant literature for analysis.[Results] A total of140 literatures were included,including 153 modeling methods. The modeling method is mostly used in compound factor modeling,and MNNG is the main modeling drug. In the aspect of modeling cycle,the average period of single factor and compound factor modeling was not statistically different.[Conclusion] The establishment of CAG model has the characteristics of longer period and higher mortality,and the establishment of stable and ideal experimental animal model still needs to be further explored.

关 键 词：慢性萎缩性胃炎 胃癌前病变 大鼠 造模方法 文献研究 

分 类 号：R573.3[医药卫生—消化系统]