Synthesis and Spectroscopic Investigations of Four New Y(Ⅲ), Ge(Ⅳ), W(Ⅵ) and Si(Ⅳ) Penicillin Antibiotic Drug Complexes  

作　　者：Abeer A.El-Habeeb Moamen S.Refat 

机构地区：[1]College of Science, Princess Nourah Bint Abdulrahman University, Department of Chemistry, Riyadh 11671, Saudi Arabia [2]Chemistry Department, Faculty of Science, Taif University, P.O. Box 888, Al-Hawiah, Taif 21974, Saudi Arabia [3]Department of Chemistry, Faculty of Science, Port Said, Port Said University, Egypt

出　　处：《光谱学与光谱分析》2019年第9期2982-2988,共7页Spectroscopy and Spectral Analysis

摘　　要：A four new penicillinate complexes were prepared through the chemical interactio ns of penicillin potassium salt (Pin) with YCl 3, GeCl 4, WCl 6 and SiCl 4 m etal ions. These metal complexes were characterized using spectroscopic techniqu es (e.g. 1H-NMR, infrared, electronic UV-Vis) as well as elemental, cond uctivity, and magnetic measurements. The molar conductance values were highly, s howing their electrolytic nature. The magnetic and electronic study strongly rec ommends the octahedral geometry of all penicillinate complexes. A monomeric stru ctures of Pin complexes are proposed with octahedral coordinated metals ions. Th e metal ions are coordinated toward Pin as tridentate ligand through the amide a nd β-lactam carbonyls and a carboxylate group from penicillin. The in vitro antimicrobial activity of all the complexes, at concentrations in μg·mL^-1 , was screened against four bacterial pathogens, namely, Bacillus subtilis , Escherichia coli, Pseudomonas aeruginosa , and Staphylococcus aureus , and two kinds of fungi Aspergillus flavus and Candida albicans showed better activi ty compared to parent drug and control drug. The anti-cancer inhibition of the tungsten(Ⅵ) complex was assessed against the human hepato cellular carcinoma (H epG-2) tumor cell line with IC50 value is 646 μg·mL^-1 .A four new penicillinate complexes were prepared through the chemical interactions of penicillin potassium salt（Pin） with YCl3, GeCl4, WCl6 and SiCl4 metal ions. These metal complexes were characterized using spectroscopic techniques（e.g. 1H-NMR, infrared, electronic UV-Vis） as well as elemental, conductivity, and magnetic measurements. The molar conductance values were highly, showing their electrolytic nature. The magnetic and electronic study strongly recommends the octahedral geometry of all penicillinate complexes. A monomeric structures of Pin complexes are proposed with octahedral coordinated metals ions. The metal ions are coordinated toward Pin as tridentate ligand through the amide and β-lactam carbonyls and a carboxylate group from penicillin. The in vitro antimicrobial activity of all the complexes, at concentrations in μg·mL-1, was screened against four bacterial pathogens, namely, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, and two kinds of fungi Aspergillus flavus and Candida albicans showed better activity compared to parent drug and control drug. The anti-cancer inhibition of the tungsten（Ⅵ） complex was assessed against the human hepato cellular carcinoma（HepG-2） tumor cell line with IC50 value is 646 μg·mL-1.

关 键 词：PENICILLIN YTTRIUM GERMANIUM TUNGSTEN SI licon FTIR COMPLEXATION Biological 

分 类 号：O657.3[理学—分析化学]