Crystallizing BubR1’s kinase activity  

作　　者：Jazeel F. Limzerwala Jan M. van Deursen 

机构地区：[1]Departments of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA [2]Departments of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA

出　　处：《Cell Research》2019年第8期605-606,共2页细胞研究（英文版）

摘　　要：BubR1 has been implicated in fundamental biological processes such as cell division, cancer, aging and age-related diseases, but whether this mitotic checkpoint protein acts as a kinase has remained a matter of intense debate. With a multi-pronged approach involving the use of structural biology, substrate identification, pharmacological inhibition of kinase activity, and functional assays, Huang et al. now provide compelling evidence that BubR1 has enzymatic activity.

关 键 词：FUNDAMENTAL DIVISION BUBR1 

分 类 号：Q[生物学]