supported by the National Natural Science Foundation of China(31970666);Taishan Scholar Project(tsqn201812054)from Shandong,China;Work at the Novo Nordisk Foundation Center for Protein Research was supported by the grant NNF14CC0001;J.N.is supported by grants from the Danish Cancer Society(R269-A15586-B17);Independent Research Fund Denmark(8021-00101B and 0134-00199B);Novo Nordisk Foundation(NNF20OC0065098).
The Bub1 and BubR1 kinetochore proteins support proper chromosome segregation and mitotic checkpoint activity. Bub1 and BubR1 are paralogs with Bub1 being a kinase, while BubR1 localizes the PP2A-B56 protein phosphata...
BubR1 has been implicated in fundamental biological processes such as cell division, cancer, aging and age-related diseases, but whether this mitotic checkpoint protein acts as a kinase has remained a matter of intens...
We are grateful to Prof. Yunyu Shi for support;to Dr Hongtao Yu for reagents and Drs Guo-Qiang Chen for input. We thank all the members of our laboratories for discussion and Qiaoqiao Zhang for help on several BubRI mutant constructs;initiated by the chemical biology grant PGX-2 from the ProteoGenomics Research Laboratory;supported in part by the National Key Research and Development Program of China (2017YFA0503600, 2017YFA0504901, 2016YFA0100500);National Natural Science Foundation of China (31320103904, 31430054, 91313303, 31621002, 31301120, 91854203, 91853115, 91753000, 31671405, 31470792, 31601097, 21672201, 31600607, and B1661138004);Strategic Priority Research Program' of the Chinese Academy of Sciences (XDB19000000 and XDB08030102);MOE Innovative team (IRT_17R102).
Error-free mitosis depends on accurate chromosome attachment to spindle microtubules, powered congression of those chromosomes, their segregation in anaphase, and assembly of a spindle midzone at mitotic exit. The cen...
Protein phosphatase 2A (PP2A) accounts for the majority of total Ser/Thr phosphatase activities in most cell types and regulates many biological processes. PP2A holoenzymes contain a scaffold A subunit, a cat- alyti...