KINETOCHORE

作品数：34被引量：48H指数：4
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相关领域：生物学更多>>
相关作者：谭彬国静王升年朱学良钱敏更多>>
相关机构：重庆医科大学中国科学技术大学中国科学院上海生命科学研究院更多>>
相关期刊：《World Journal of Gastrointestinal Surgery》《Plant Communications》《辐射研究与辐射工艺学报》《Journal of Clinical and Translational Hepatology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金重庆市自然科学基金更多>>
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ZW10:an emerging orchestrator of organelle dynamics during the cell division cycle
《Journal of Molecular Cell Biology》2024年第7期1-11,共11页Sm Faysal Bellah Fengrui Yang Fangyuan Xiong Zhen Dou Xuebiao Yao Xing Liu 
supported by grants from the Ministry of Science and Technology of China and the National Natural Science Foundation of China(2022YFA1303100,32090040,92254302,2022YFA0806800,W2411017,32450537,91953000,92153302,32170733,and 22177106);Plans for Major Provincial Science&Technology Projects of Anhui Province(202303a0702003);the Ministry of Education(IRT_17R102);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB19040000);the Fundamental Research Funds for the Central Universities(KB9100000007,KB9100000006,and KB9100000013).
Zeste white 10(ZW10)was first identified as a centromere/kinetochore protein encoded by the ZW10 gene in Drosophila.ZW10 guides the spindle assembly checkpoint signaling during mitotic chromosome segregation in metazo...
关键词：ZW10 KINETOCHORE membrane-bound organelle membraneless organelle MITOSIS 
Aurora B promotes the CENP-T–CENP-W interaction to guide accurate chromosome segregation in mitosis
《Journal of Molecular Cell Biology》2024年第2期11-23,共13页Wei Liu Zhen Dou Chunyue Wang Gangyin Zhao Fengge Wu Chunli Wang Felix Aikhionbare Mingliang Ye Divine Mensah Sedzro Zhenye Yang Chuanhai Fu Zhikai Wang Xinjiao Gao Xuebiao Yao Xiaoyu Song Xing Liu 
supported by the National Key Research and Development Program of China(2022YFA1303100,2022YFA0806800,2022YFA1302700,and 2017YFA0503600);the National Natural Science Foundation of China(32090040,92254302,92153302,92253301,22137007,32170733,and 31871359);the Ministry of Education(IRT_17R102);the Plans for Major Provincial Science&Technology Projects of Anhui Province(202303a0702003);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB19040000);the Fundamental Research Funds for the Central Universities(WK2070000066 and WK2070000194).
Accurate chromosome segregation in mitosis depends on kinetochores that connect centromeric chromatin to spindle microtubules.Centromeres are captured by individual microtubules via a kinetochore constitutive centrome...
关键词：MITOSIS KINETOCHORE Aurora B CENP-T CENP-W PHOSPHORYLATION 
PLK1 phosphorylation of ZW10 guides accurate chromosome segregation in mitosis
《Journal of Molecular Cell Biology》2024年第2期47-62,共16页Sm Faysal Bellah Fangyuan Xiong Zhen Dou Fengrui Yang Xing Liu Xuebiao Yao Xinjiao Gao Liangyu Zhang 
supported by grants from the Ministry of Science and Technology of China and the National Natural Science Foundation of China(2022YFA1303100,32090040,92254302,2022YFA0806800,91854203,31621002,2017YFA0503600,21922706,and 92153302 to X.L.;92053104 to X.G.);the Plans for Major Provincial Science&Technology Projects of Anhui Province(202303a0702003 to X.L.);the Ministry of Education(IRT_17R102 to X.L.);the Fundamental Research Funds for the Central Universities(KB9100000007 and KB9100000013 to X.L.)。
Stable transmission of genetic information during cell division requires faithful chromosome segregation.Mounting evidence has demonstrated that polo-like kinase 1(PLK1)dynamics at kinetochores control correct kinetoc...
关键词：ZW10 PLK1 KINETOCHORE MITOSIS PHOSPHORYLATION 
Sgo1 interacts with CENP-A to guide accurate chromosome segregation in mitosis
《Journal of Molecular Cell Biology》2023年第10期26-38,共13页Fengge Wu Hameed Akbar Chunyue Wang Xiao Yuan Zhen Dou McKay Mullen Liwen Niu Liang Zhang Jianye Zang Zhikai Wang Xuebiao Yao Xiaoyu Song Xing Liu 
supported by grants from the Ministry of Science and Technology of China(2022YFA1303100,2022YFA0806800,2022YFA1302700,and 2017YFA0503600);the National Natural Science Foundation of China(32090040,92254302,92153302,32170733,31621002,and 22177106);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB19040000 and XDB37010105);the Ministry of Education(IRT_17R102,20113402130010,and YD2070006001).
Shugoshin-1(Sgo1)is necessary for maintaining sister centromere cohesion and ensuring accurate chromosome segregation during mitosis.It has been reported that the localization of Sgo1 at the centromere is dependent on...
关键词：MITOSIS CENTROMERE KINETOCHORE Sgo1 CENP-A Aurora B 
High spindle and kinetochore-associated complex subunit-3 expression predicts poor prognosis and correlates with adverse immune infiltration in hepatocellular carcinoma
《World Journal of Gastrointestinal Surgery》2023年第8期1600-1614,共15页Lin-Lin Zheng Ya-Ru Wang Zhen-Rong Liu Zhi-Hao Wang Chang-Cheng Tao Yong-Gang Xiao Kai Zhang An-Ke Wu Hai-Yang Li Jian-Xiong Wu Ting Xiao Wei-Qi Rong 
Beijing Hope Run Special Fund of Cancer Foundation of China,No.LC2020L05.
BACKGROUND Spindle and kinetochore-associated complex subunit 3(SKA3)is a malignancyassociated gene that plays a critical role in the regulation of chromosome separation and cell division.However,the molecular mechani...
关键词：Spindle and kinetochore-associated protein 3 Hepatocellular carcinoma Prognosis Immune infiltration cells 
High temperature increases centromeremediated genome elimination frequency and enhances haploid induction in Arabidopsis
《Plant Communications》2023年第3期126-138,共13页Ulkar Ahmadli Manikandan Kalidass Lucie Crhak Khaitova Joerg Fuchs Maria Cuacos Dmitri Demidov Sheng Zuo Jana Pecinkova Martin Mascher Mathieu Ingouff Stefan Heckmann Andreas Houben Karel Riha Inna Lermontova 
supported by the German Federal Ministry of Education and Research(Plant 2030,Project 031B0192NN,HaploTools);the Deutsche Forschungsgemeinschaft(LE2299/3-1 and LE2299/5-1);the European Regional Development Fund-Project"REMAP"(CZ.02.1.01/0.0/0.0/15_003/0000479)to K.R.
Double haploid production is the most effective way to create true-breeding lines in a single generation.In Arabidopsis,haploid induction via mutation of the centromere-specific histone H3(cenH3)has been shown when th...
关键词：CENTROMERE kinetochore null 2 CENPC-k cenh3-4 temperature stress haploid induction 
Spindle and Kinetochore-associated Family Genes are Prognostic and Predictive Biomarkers in Hepatocellular Carcinoma
《Journal of Clinical and Translational Hepatology》2022年第4期627-641,共15页Chenhui Cai Ying Zhang Xu Hu Sizhen Yang Jiawen Ye Zihan Wei Tongwei Chu 
This research was funded by the General project of Chongqing Natural Science Foundation of China(No.cstc2020jcyjmsxmX0688);National Key Research and Development Plan Project(2016YFC1101504);the Clinical Research Project of the Second Affiliated Hospital of the Army Military Medical University(2018XLC2016).
Background and Aims:Hepatocellular carcinoma(HCC)is one of the most frequent malignant tumors.Spindle and kinetochore-associated(SKA)family genes are essential for the maintenance of the metaphase plate and spindle ch...
关键词：Spindle and kinetochore-associated genes Liver hepatocellular carcinoma Prognostic value Immune infiltration Bioinformatics analysis 
Phosphorylation of CENP-R by Aurora B regulates kinetochore-microtubule attachment for accurate chromosome segregation被引量：2
《Journal of Molecular Cell Biology》2022年第7期62-75,共14页Divine Mensah Sedzro Xiao Yuan McKay Mullen Umer Ejaz Tongtong Yang Xu Liu Xiaoyu Song Yun-Chi Tang Weijun Pan Peng Zou Xinjiao Gao Dongmei Wang Zhikai Wang Zhen Dou Xing Liu Xuebiao Yao 
Ministry of Science and Technology of China(MOST)grants(2017YFA0503600);National Natural Science Foundation of China(NSFC)grants(91854203,31621002,91853115,21922706,92153302,32090040,22177106,31871359,92053104,32100612,22137007,and 31970655);Ministry of Education(IRT_17R102,20113402130010,and YD2070006001);Strategic Priority Research Program of the Chinese Academy of Sciences(XDB19040000);Anhui Provincial Natural Science Foundation Grant(2108085J15 and 1908085MC64);Fundamental Research Funds for the Central Universities(WK2070000066 and WK2070000194).
Error-free mitosis depends on accurate chromosome attachment to spindle microtubules via a fine structure called the centromere that is epigenetically specified by the enrichment of CENP-A nucleosomes.Centromere maint...
关键词：constitutive centromere-associated network(CCAN) KINETOCHORE MICROTUBULE Aurora B CENP-R PHOSPHORYLATION 
CRISPR/Cas9 screening identifies a kinetochore-microtubule dependent mechanism for Aurora-A inhibitor resistance in breast cancer被引量：2
《Cancer Communications》2021年第2期121-139,共19页Ailin Chen Shijun Wen Fang Liu Zijian Zhang Meiling Liu Yuanzhong Wu Bin He Min Yan Tiebang Kang Eric W-F Lam Zifeng Wang Quentin Liu 
This research work was supported by the National Key R&D Program of China(2019YFA0110300 and 2017YFA0505600-04 to QL);the National Natural Science Foundation of China(81820108024 and 81630005 to QL,81773166 to ZFW);the Innovative Research Team at the University of Ministry of Education of China(IRT-17R15 to QL);the Natural Science Foundation of Guangdong(2016A030311038 and 2017A030313608 to QL,2017A020215098 to ZFW);the Science and Technology Planning Project of Guangzhou(201804020044 to QL).
Background:Overexpression of Aurora-A(AURKA)is a feature of breast cancer and associates with adverse prognosis.The selective Aurora-A inhibitor alisertib(MLN8237)has recently demonstrated promising antitumor response...
关键词：alisertib AURORA-A breast cancer CHR-6494 CRISPR/Cas9 screening haspin kinetochoremicrotubule mitotic centromere-associated kinesin synthetic lethal XENOGRAFT 
Mps1 dimerization and multisite interactions with Ndc80 complex enable responsive spindle assembly checkpoint signaling被引量：1
《Journal of Molecular Cell Biology》2020年第7期486-498,共13页Ping Gui Divine M.Sedzro Xiao Yuan Sikai Liu Mohan Hei Wei Tian Najdat Zohbi Fangwei Wang Yihan Yao Felix O.Aikhionbare Xinjiao Gao Dongmei Wang Xuebiao Yao Zhen Dou 
supported by the National Key R&D Program of China(2017YFA 0102900 and 2017 YFA 0503600);the National Natural Science Fondation of China(31671407 and 31871359 to Z.D.;31621002,31430054,91854203,and 31320103904 to X.Y.;31301099 and 21672201 to X.G.;31471275 to D.W.),Strategic Priority Research Program of the Chinese Academy of Sciences(XDB19040000);Chinese Academy of Sciences Center for Excellence in Molecular Cell Science(2015 HSC-UE010);MOE Innovative Team(IRT_17R102).
Error-free mitosis depends on accurate chromosome attachment to spindle microtubules,which is monitored by the spindle assembly checkpoint(SAC)signaling.As an upstream factor of SAC,the precise and dynamic kinetochore...
关键词：MITOSIS spindle assembly checkpoint KINETOCHORE Mps1 kinase Ndc80 complex 
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