XENOGRAFT

作品数：169被引量：569H指数：12
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相关领域：医药卫生更多>>
相关作者：杨永广何冬梅龙江郭雅婷王琪更多>>
相关机构：哈佛大学复旦大学附属肿瘤医院福建省肿瘤医院中国医药大学更多>>
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Single-cell transcriptomic sequencing identifies subcutaneous patient-derived xenograft recapitulated medulloblastoma
《Animal Models and Experimental Medicine》2025年第3期458-472,共15页Jiayu Gao Yahui Zhao Ziwei Wang Fei Liu Xuan Chen Jialin Mo Yifei Jiang Yongqiang Liu Peiyi Tian Yanong Li Kaiwen Deng Xueling Qi Dongming Han Zijia Liu Zhengtao Yang Yixi Chen Yujie Tang Chunde Li Hailong Liu Jiankang Li Tao Jiang 
National Key Research and Development Program of China,Grant/Award Number:2022ZD0210100;Beijing Nova Star Program,Grant/Award Number:2022002;Natural Science Foundation of Beijing and Haidian Collaboration Foundation,Grant/Award Number:L232079;National Natural Science Foundation of China,Grant/Award Number:82172608,82273343,81902975 and 82101356;Capital Medical University Fund for Excellent Young Scholars,Grant/Award Number:KCB2304。
Background:Medulloblastoma(MB)is one of the most common malignant brain tumors that mainly affect children.Various approaches have been used to model MB to facilitate investigating tumorigenesis.This study aims to com...
关键词：experimental models MEDULLOBLASTOMA single-cell sequencing sPDX 
A surgical orthotopic xenograft approach with immune response for colorectal cancer research
《Animal Models and Experimental Medicine》2025年第3期558-567,共10页Xiaoying Hou Xiaoxuan Li Qian Fang Yufei Deng Haiping Wang Binlian Sun Chengliang Zhang Hongzhi Du Yuchen Liu 
Research Fund of Jianghan University,Grant/Award Number:2021jczx-002;Natural Science Foundation of Hubei Province,Grant/Award Number:2024AFB941 and 2024AFD241;Wuhan Science and Technology Project,Grant/Award Number:2023010201020448;National Natural Science Foundation of China,Grant/Award Number:82204416。
The high morbidity and mortality of colorectal cancer(CRC)is a major challenge in clinical practice.Although a series of alternative research models of CRC have been developed,appropriate orthotopic animal models that...
关键词：animal model colorectal cancer orthotopic tumor model tumor immunology 
Continuous immunosuppression is required for suppressing immune responses to xenografts in non‑human primate brains
《Cell Regeneration》2024年第1期305-314,共10页Su Feng Ting Zhang Zhengxiao He Wenchang Zhang Yingying Chen Chunmei Yue Naihe Jing 
National Key Basic Research and Development Program of China(2019YFA0801402,2018YFA0107200,2018YFA0801402,2018YFA0800100);Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16020501,XDA16020404);National Natural Science Foundation of China(32130030,31900454).
Continuous immunosuppression has been widely used in xenografts into non-human primate brains.However,how immune responses change after transplantation in host brains under continuous immunosuppressive adminis-tration...
关键词：Cell transplantation XENOGRAFT Immune response Non-human primate brain Human induced neural stem/progenitor cells(iNPCs) 
Targeting NUF2 suppresses gastric cancer progression through G2/M phase arrest and apoptosis induction
《Chinese Medical Journal》2024年第20期2437-2451,共15页Bo Long Huinian Zhou Lixia Xiao Xiangyan Jiang Jian Li Zhijian Ma Na He Wei Xin Boya Zhang Xiaoqin Zhu Zeyuan Yu Zuoyi Jiao 
supported by grants from the National Natural Science Foundation of China(Nos.32170729 and 8216100622);Major Project Granted by the Gansu Provincial Science and Technology Department(No.21ZD4FA015);the Gansu Provincial Science and Technology Plan Project 21(No.JR1RA144);the Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital(No.CY2020-MS10);Gansu Province Science Foundation for Youths(20JR5RA316);the Cuiying Science and Technology Innovation Project of Lanzhou University Second Hospital(Nos.CYXZ2020-10,CY2020-MS10,CYXZ2021-27,and CY2022-ZD-01).
Background:Gastric cancer(GC),a malignant tumor with poor prognosis,is one of the leading causes of cancer-related deaths worldwide;consequently,identifying novel therapeutic targets is crucial for its corresponding t...
关键词：NUF2 Gastric cancer QUERCETIN Patient-derived xenograft Organoid 
Defining and tracing subtypes of patient-derived xenograft models in pancreatic ductal adenocarcinoma
《Cancer Communications》2024年第8期915-920,共6页Sangyeop Hyun Youngmin Han Jae Yun Moon Young-Ah Suh Won-Gun Yun Wooil Kwon Jong-Eun Lee Daeun Kim Ja-Lok Ku Jin-Young Jang Daechan Park 
supported by Global-Learning&Academic research institution for Master’s PhD students,Postdocs(G-LAMP)Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(RS-2023-00285390 to Daechan Park);the NRF grant funded by the Ministry of Science and ICT(RS-2024-00341899 to Daechan 2022R1A2C2011122 to Jin-Young Jang);supported by DNA Link,Inc.,and there is no conflict of interest.
Patient-derived xenograft(PDX)models have been used to explore therapeutic opportunities for pancreatic ductal adenocarcinoma(PDAC)[1].Although original tumor characteristics are altered by cancer-stromal interactions...
关键词：ADENOCARCINOMA DUCTAL XENOGRAFT 
Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids被引量：9
《Protein & Cell》2024年第4期285-304,共20页Yunuo Mao Wei Wang Jingwei Yang Xin Zhou Yongqu Lu Junpeng Gao Xiao Wang Lu Wen Wei Fu Fuchou Tang 
funded by the Beijing Advanced Innovation Center for Genomics and the National Natural Science Foundation of China(Grant No.91959110).
Colorectal cancer(CRC)is a highly heterogeneous cancer and exploring novel therapeutic options is a pressing issue that needs to be addressed.Here,we established human CRC tumor-derived organoids that well represent b...
关键词：colorectal cancer ORGANOIDS drug repurposing patient-derived organoids-based xenograft mechanism of action 
Application of patient-derived tumor models in anticancer drug development and individualized medicine
《Life Research》2024年第1期3-9,共7页Kai-Ling Chen Yu-Fei Deng Xiao-Ying Hou Yu-Chen Liu 
the Scientific Research Project Funding of Jianghan University(2023zd053);The Scientific Research Project Funding of Jianghan University(2021jczx-002).
Malignant tumor is the second leading cause of death due to its high incidence, lack of effective treatment and poor prognosis. The evaluation of anticancer drugs used to based on NCI-60 cell line models, but the limi...
关键词：patient-derived xenograft(PDX) patient-derived organoid(PDO) patient-derived cell(PDC) individualized medicine 
The BET inhibitor sensitivity is associated with the expression level of CDC25B in pancreatic cancer models
《Cancer Drug Resistance》2024年第1期297-308,共12页Aubrey L.Miller Patrick L.Garcia Rebecca B.Vance Eric O.Heard Eric J.Brown Karina J.Yoon 
NIH grant R01CA208272(to Yoon KJ).
Aim:Cell division cycle 25B(CDC25B)belongs to the CDC25 family of phosphatases that regulate cell cycle progression.CDC25B also contributes to tumor initiation and progression,but no connection between CDC25B levels a...
关键词：Cell division cycle 25B(CDC25B) pancreatic ductal adenocarcinoma(PDAC) GEMCITABINE patient-derived xenograft(PDX)models BET inhibitor(BETi) gemcitabine-resistant(gemR)models 
Vascularization ability of glioma stem cells in different three-dimensional microenvironments被引量：1
《Regenerative Biomaterials》2024年第1期34-43,共10页Xuanzhi Wang Tao Xu Chaoshi Niu 
supported by the Anhui Provincial Natural Science Foundation(2308085MH279);the Fundamental Research Funds for the Central Universities(WK9110000156);Key Research and Development Program of Anhui Province(202104j07020025);2021 Anhui Provincial Quality Engineering Project for Higher Education Institutions(2021jyxm1778).
Glioblastoma(GBM)is among the most common and aggressive adult central nervous system tumors.One prominent charac-teristic of GBM is the presence of abnormal microvessels.A significant correlation between angiogenesis...
关键词：3D bioprinting xenograft tumors GSC-laden hydrogel scaffold GLIOBLASTOMA angiogenesis 
The evolution of cancer genomic medicine in Japan and the role of the National Cancer Center Japan被引量：1
《Cancer Biology & Medicine》2024年第1期29-44,共16页Teruhiko Yoshida Yasushi Yatabe Ken Kato Genichiro Ishii Akinobu Hamada Hiroyuki Mano Kuniko Sunami Noboru Yamamoto Takashi Kohno 
The journey to implement cancer genomic medicine(CGM)in oncology practice began in the 1980s,which is considered the dawn of genetic and genomic cancer research.At the time,a variety of activating oncogenic alteration...
关键词：Cancer genomic medicine BIOBANK patient-derived xenograft multi-gene panel test whole genome sequencing 
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