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神经影像学变化与骨坏死的关联:UK Biobank及FinnGen数据库的大样本分析
《中国组织工程研究》2025年第30期6574-6582,共9页张博淳 李威 李广政 丁浩秦 李刚 梁学振 
国家自然科学基金面上项目(82074453),项目负责人:李刚;国家自然科学基金青年项目(82205154),项目负责人:梁学振;山东省自然科学基金青年项目(ZR2021QH004),项目负责人:梁学振;山东省自然科学基金面上项目(ZR2024MH156),项目负责人:梁学振。
背景:随着对骨坏死发病机制的不断探索研究,越来越多的研究证据显示神经影像学变化与骨坏死的发病存在密切联系,然而神经影像学变化与骨坏死的具体因果关联尚不明确。目的:采用孟德尔随机化评估神经影像学指标与骨坏死之间的因果联系。...
关键词：神经影像学 骨坏死 因果关系 孟德尔随机化 工程化组织构建 
血浆蛋白与骨质疏松症的关系及潜在治疗靶点:基于国际UK Biobank数据库信息
《中国组织工程研究》2025年第18期3948-3960,共13页朱凯 刘宛欣 罗昊冰 冯圣一 王秋根 
上海中医药大学预算内项目(KY110.01.423),项目负责人:冯圣一;岳阳医院优教人才培养项目(JY611.20.04.05),项目负责人:冯圣一。
背景:骨质疏松症是全球范围内增加疾病负担和致残率的重要因素。血浆蛋白参与体内复杂的生物过程,在揭示疾病机制和发现潜在治疗靶点方面起着关键作用。尽管已有研究显示血浆蛋白与骨质疏松症之间存在关联,但这些关联的因果性质尚未得...
关键词：血浆蛋白 蛋白质数量性状位点 骨质疏松症 孟德尔随机化 因果关系 富集分析 免疫 趋化 生物标记物 药物靶点 
Dietary carbohydrate intake and risk of type 2 diabetes:a 16-year prospective cohort study
《Science China(Life Sciences)》2025年第4期1149-1157,共9页Lu Gan Yi Yang Bin Zhao Kai Yu Kehua Guo Fang Fang Zhiguang Zhou Demetrius Albanes Jiaqi Huang 
supported by the Noncommunicable Chronic Diseases-National Science and Technology Major Project(2023ZD0508200,2023ZD0508201);the National Natural Science Foundation of China(82100949,82470931);the Outstanding Young Investigator Award of Hunan Province(2022JJ10094);Central South University Research Programme of Advanced Interdisciplinary Studies(2023QYJC008)to J.H;the Intramural Research Program of the U.S.National Cancer Institute(NCI),National Institutes of Health(NIH)to D.A。
Despite considerable research underscoring the importance of carbohydrate intake in relation to the risk of type 2 diabetes(T2D),a comprehensive assessment of this relationship is currently lacking.We aimed to examine...
关键词：dietary carbohydrate type 2 diabetes prospective cohort study UK Biobank 
Comment on“physical activity volume,intensity and life expectancy”
《Journal of Sport and Health Science》2025年第1期1-2,共2页Barbara E.Ainsworth Zeyun Feng 
In the new released article of the Journal of Sport and Health Science,Zaccardi et al.1 provide compelling evidence that engaging in higher volumes and intensities of physical activity(PA)increases life expectancy in ...
关键词：accelerometers physical activity pa increases physical activity life expectancy older adults UK Biobank 
Enhancing clinical and public health interpretation of accelerometer-assessed physical activity with age-referenced values based on UK Biobank data
《Journal of Sport and Health Science》2025年第1期27-37,共11页Alex V.Rowlands Andrew P.Kingsnorth Bjørge H.Hansen Stuart J.Fairclough Lynne M.Boddy Benjamin D.Maylor Henrik R.Eckmann Borja del Pozo Cruz Nathan P.Dawkins Cameron Razieh Kamlesh Khunti Francesco Zaccardi Tom Yates 
supported by the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre and NIHR Applied Research Collaboration East Midlands (ARC EM, (IS-BRC-1215-20010));funded by the National Institute for Health and Care Research Bristol Biomedical Research Centre (IS-BRC-1215-20011);supported by a UKRI research grant (EP/X042464/1)。
Background Higher accelerometer-assessed volume and intensity of physical activity(PA)have been associated with a longer life expectancy but can be difficult to translate into recommended doses of PA.We aimed to:(a)im...
关键词：Physical activity recommendations Average acceleration Intensity gradient MODERATE Vigorous 
Living biobank:Standardization of organoid construction and challenges被引量：1
《Chinese Medical Journal》2024年第24期3050-3060,共11页Ruixin Yang Yao Qi Xiaoyan Zhang Hengjun Gao Yingyan Yu 
supported by grants from the National Natural Science Foundation of China(Nos.82473013 and 82072602);the Shanghai Science and Technology Committee(No.20DZ2201900);the Innovation Foundation of Translational Medicine of Shanghai Jiao Tong University School of Medicine(No.TM202001);the Collaborative Innovation Center for Clinical and Translational Science by Chinese Ministry of Education&Shanghai Municipal Government(Nos.CCTS-2022202 and CCTS-202302).
In multiple areas such as science,technology,and economic activities,it is necessary to unify the management of repetitive tasks or concepts by standardization to obtain the best order and high efficiency.Organoids,as...
关键词：Living biobank Organoid STANDARDIZATION GUIDELINES Laboratory construction 
Associations of diet with infectious diseases in UK Biobank被引量：1
《Journal of Biomedical Research》2024年第6期597-612,共16页Junlan Tu Xuehong Cai Yifan Wang Xiangyu Ye Meijie Yu Sheng Yang Rongbin Yu Peng Huang 
supported by the National Natural Science Foundation of China(Grant Nos.82173585 and 82273741);the Natural Science Foundation of Jiangsu Higher Education Institutions of China(Grant Nos.21KJB330005 and 22KJB330007);the Nanjing Major Science and Technology Project(Grant No.2021-11005);the Priority Academic Program Development of Jiangsu Higher Education Institutions.
The current study used multivariable logistic regression analysis to investigate associations between the intake frequencies of 13 food groups(or four diet groups)and infectious diseases.The analysis included 487849 p...
关键词：infectious diseases DIET food groups UK Biobank mediation analysis 
Association between Abortion and All-Cause and Cause-Speciffc Premature Mortality:A Prospective Cohort Study from the UK Biobank
《Health Data Science》2024年第1期203-214,共12页Shaohua Yin Yingying Yang Qin Wang Wei Guo Qian He Lei Yuan Keyi Si 
supported by the Shanghai Hospital Development Center(SHDC2023CRS027);Shanghai First Maternity and Infant Hospital(2023A13).
Background:Concerns have been raised about the increasing prevalence of both spontaneous and induced abortions worldwide,yet their effect on premature mortality remains poorly understood.We aimed to examine the associ...
关键词：ALONE HYPERTENSIVE LINKAGE 
Association of alcohol consumption with aortic aneurysm and dissection risk:results from the UK Biobank cohort study
《World Journal of Emergency Medicine》2024年第6期465-474,共10页Yaowen Liang Guoxiang Zou Dingchen Wang Weiyue Zeng Jiarui Zhang Xiaoran Huang Miao Lin Cong Mai Fei'er Song Yuelin Zhang Jinxiu Meng Hongliang Feng Yu Huang Xin Li 
supported by grants from the Ministry of Science and Technology of the People’s Republic of China,(No.2020AAA0109605 to XL);grants from the National Natural Science Foundation of China(No.82272246 and 82072225 to XL);Science and Technology Program of Guangzhou,China(No.202206010044 to XL);High-level Hospital Construction Project of Guangdong Provincial People’s Hospital(No.DFJHBF202104 to XL).
BACKGROUND:Previous studies have reported inconsistent results with positive,negative,and J-shaped associations between alcohol consumption and the hazard of aortic aneurysm and dissection(AAD).This study aimed to exa...
关键词：Alcohol consumption Aortic aneurysm and dissection Genetic risk score Cohort study UK Biobank 
A biobank of patient derived glioma organoids
《Science China(Life Sciences)》2024年第12期2780-2782,共3页Yulin Wen Hongmin Bai Qing Li Sainan Huang Xiaokun Jia Guangjin Pan Hongjie Yao 
supported by the Guangzhou Key R&D Program (2023B03J1230);the National Key Research and Development Program of China (2021YFA1100300);the National Natural Science Foundation of China (32430016,31925009,U21A20195);Self-supporting Program of Guangzhou Laboratory (GZNL2023A02010)。
Dear Editor,Gliomas are the most prevalent malignant tumors affecting the central nervous system(CNS),categorized into low-grade gliomas(LGG)comprising CNS WHO grades 2–3,and high-grade gliomas(HGG)encompassing CNS W...
关键词：GLIOMA ARMSTRONG 
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