Vascularization ability of glioma stem cells in different three-dimensional microenvironments  

作　　者：Xuanzhi Wang Tao Xu Chaoshi Niu 

机构地区：[1]Department of Neurosurgery,The First Affliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,Anhui,230036,China [2]Department of Neurosurgery,Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China,Chengdu 610072,People's Republic of China [3]Center for Bio-intelligent Manufacturing and Living Matter Bioprinting,Research Institute of Tsinghua University in Shenzhen,Tsinghua University,Shenzhen 518057,People's Republicof China

出　　处：《Regenerative Biomaterials》2024年第1期34-43,共10页再生生物材料（英文版）

基　　金：supported by the Anhui Provincial Natural Science Foundation(2308085MH279);the Fundamental Research Funds for the Central Universities(WK9110000156);Key Research and Development Program of Anhui Province(202104j07020025);2021 Anhui Provincial Quality Engineering Project for Higher Education Institutions(2021jyxm1778).

摘　　要：Glioblastoma(GBM)is among the most common and aggressive adult central nervous system tumors.One prominent charac-teristic of GBM is the presence of abnormal microvessels.A significant correlation between angiogenesis and prognosis has been observed.Accurately reconstructing this neovascula-rization and tumor microenvironment through personalized in vitro disease models presents a significant challenge.However,it is crucial to develop new anti-angiogenic therapies for GBM.In this study,3D bioprinted glioma stem cell(GSC)-laden hydrogel scaffolds,hybrid Gsc hydrogels and ceil-free hydrogel scaffolds were manufactured to investigate the vas-cularization ability of GsCs in varying 3D microenvironments.

关 键 词：3D bioprinting xenograft tumors GSC-laden hydrogel scaffold GLIOBLASTOMA angiogenesis 

分 类 号：R739.41[医药卫生—肿瘤]