ZW10:an emerging orchestrator of organelle dynamics during the cell division cycle  

作　　者：Sm Faysal Bellah Fengrui Yang Fangyuan Xiong Zhen Dou Xuebiao Yao Xing Liu 

机构地区：[1]MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics,University of Science and Technology of China School of Life Sciences,Hefei 230026,China [2]Anhui Key Laboratory for Cellular Dynamics and Chemical Biology,Hefei National Research Center for Interdisciplinary Sciences at the Microscale,Hefei 230027,China

出　　处：《Journal of Molecular Cell Biology》2024年第7期1-11,共11页分子细胞生物学报(英文版)

基　　金：supported by grants from the Ministry of Science and Technology of China and the National Natural Science Foundation of China(2022YFA1303100,32090040,92254302,2022YFA0806800,W2411017,32450537,91953000,92153302,32170733,and 22177106);Plans for Major Provincial Science&Technology Projects of Anhui Province(202303a0702003);the Ministry of Education(IRT_17R102);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB19040000);the Fundamental Research Funds for the Central Universities(KB9100000007,KB9100000006,and KB9100000013).

摘　　要：Zeste white 10(ZW10)was first identified as a centromere/kinetochore protein encoded by the ZW10 gene in Drosophila.ZW10 guides the spindle assembly checkpoint signaling during mitotic chromosome segregation in metazoans.Recent studies have shown that ZW10 is also involved in membrane-bound organelle interactions during interphase and plays a vital role in membrane transport between the endoplasmic reticulum and Golgi apparatus.Despite these findings,the precise molecular mechanisms by which ZW10 regulates interactions between membrane-bound organelles in interphase and the assembly of membraneless organelle kinetochore in mitosis remain elusive.Here,we highlight how ZW10 forms context-dependent protein complexes during the cell cycle.These complexes are essential for mediating membrane trafficking in interphase and ensuring the accurate segregation of chromosomes in mitosis.

关 键 词：ZW10 KINETOCHORE membrane-bound organelle membraneless organelle MITOSIS 

分 类 号：O62[理学—有机化学]