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Empowering the NSC-34 cell line as a motor neuron model: Cytosine arabinoside's action: 《Neural Regeneration Research》2026年第1期357-364,共8页Giuseppe Vitale Susanna Amadio Francesco Liguori Cinzia Volonté; supported by FATALSDrug Project [Progetti di Ricerca@CNR SAC.AD002.173.058] from National Research Council,Italy (to CV)。; The NSC-34 cell line is a widely recognized motor neuron model and various neuronal differentiation protocols have been exploited. Under previously reported experimental conditions, only part of the cells resemble dif...; 关键词：cytosine arabinoside Islet2 Hb9 Ki67 mitosis inhibition neurite initiation neurite regeneration neuronal differentiation protocol NSC-34 P75

The Pathophysiologic Role of Oxidative Stress in Mitotic Cell Division: 《BIOCELL》2025年第3期419-435,共17页Nathan Isaac Dibal Martha Orendu Oche Attah; Oxidative stress is characterized by elevated intracellular reactive oxygen species(ROS)levels.At physiological levels,ROS work as signaling molecules,helping cells go through the cell cycle normally and keeping their...; 关键词：Cell cycle MITOSIS oxidative stress ROS

Potential regulatory mechanism and clinical significance of synaptotagmin binding cytoplasmic RNA interacting protein in colorectal cancer: 《World Journal of Clinical Oncology》2024年第11期1412-1427,共16页Hui Li He-Qing Huang Zhi-Guang Huang Rong-Quan He Ye-Ying Fang Rui Song Jia-Yuan Luo Da-Tong Zeng Kai Qin Dan-Ming Wei Gang Chen; Supported by Guangxi Zhuang Autonomous Region Health Commission Scientific Research Project,No.Z-A20220415 and No.Z20210442;The First Affiliated Hospital of Guangxi Medical University Provincial and Ministerial Key Laboratory Cultivation Project:Guangxi Laboratory of Enhanced Recovery after Surgery for Gastrointestinal Cancer,No.21-220-18.; BACKGROUND Colorectal cancer(CRC)causes many deaths worldwide.Synaptotagmin binding cytoplasmic RNA interacting protein(SYNCRIP)is an RNA-binding protein that plays an important role in multiple cancers by epigenetica...; 关键词：Synaptotagmin binding cytoplasmic RNA interacting protein Colorectal cancer Radiotherapy Cell mitosis Immune microenvironment

ZW10:an emerging orchestrator of organelle dynamics during the cell division cycle: 《Journal of Molecular Cell Biology》2024年第7期1-11,共11页Sm Faysal Bellah Fengrui Yang Fangyuan Xiong Zhen Dou Xuebiao Yao Xing Liu; supported by grants from the Ministry of Science and Technology of China and the National Natural Science Foundation of China(2022YFA1303100,32090040,92254302,2022YFA0806800,W2411017,32450537,91953000,92153302,32170733,and 22177106);Plans for Major Provincial Science&Technology Projects of Anhui Province(202303a0702003);the Ministry of Education(IRT_17R102);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB19040000);the Fundamental Research Funds for the Central Universities(KB9100000007,KB9100000006,and KB9100000013).; Zeste white 10(ZW10)was first identified as a centromere/kinetochore protein encoded by the ZW10 gene in Drosophila.ZW10 guides the spindle assembly checkpoint signaling during mitotic chromosome segregation in metazo...; 关键词：ZW10 KINETOCHORE membrane-bound organelle membraneless organelle MITOSIS

精子发生中小非编码RNA的新见解: 《Science Bulletin》2024年第11期1581-1585,共5页王鑫张振翼赵爽刘默芳; supported by the National Key R&D Program of China (2021YFC2700200 and 2022YFA1303300);National Natural Science Foundation of China (32330053,31830109,31821004,32271347,32101037 and 32071286);Science and Technology Commission of Shanghai Municipality (19JC1410200,21YF1452700 and 21ZR1470500);Zhejiang Provincial Natural Science Foundation of China (LZ23C050001);the Young Elite Scientist Sponsorship Program of the China Association for Science and Technology (2021QNRC001);the Research Funds of Hangzhou Institute for Advanced Study,UCAS(2023HIAS-Y022);the Foundation of Key Laboratory of Gene Engineering of the Ministry of Education;the New Cornerstone Science Foundation (NCI202329)。; Spermatogenesis is one of the most complicated cell differentiation processes in animals, which consists of mitosis, meiosis, and the post-meiotic phase of male germ cell development, i.e.,spermiogenesis. Mitosis is r...; 关键词：精子发生 maintenance MITOSIS

RETINOBLASTOMA RELATED 1 switches mitosis to meiosis in rice: 《Plant Communications》2024年第6期193-212,共20页Yongjie Miao Hanli You Huixin Liu Yangzi Zhao Jiangzhe Zhao Yafei Li Yi Shen Ding Tang Baohui Liu Kewei Zhang Zhukuan Cheng; supported by grants from the National Natural Science Foundation of China(U2102219,32201779,and 31930018);the Natural Science Foundation of Zhejiang Province(LZ23C020001).; The transition from mitosis to meiosis is a critical event in the reproductive development of all sexually reproducing species.However,the mechanisms that regulate this process in plants remain largely unknown.Here,we...; 关键词：RETINOBLASTOMA RELATED1 meiosis initiation CYTOKININ RICE

Chromothripsis:an emerging crossroad from aberrant mitosis to therapeutic opportunities: 《Journal of Molecular Cell Biology》2024年第4期1-16,共16页Umer Ejaz Zhen Dou Phil YYao Zhikai Wang Xing Liu Xuebiao Yao; supported by the Ministry of Science and Technology of China and the National Natural Science Foundation of China(2022YFA1303100,32090040,92254302,2022YFA0806800,91854203,31621002,2017YFA0503600,21922706,92153302 to X.L.,2022YFA1302700 to Z.W.);the Ministry of Education(IRT_17R102,20113402130010,YD2070006001 to X.L.);the Fundamental Research Funds for the Central Universities(WK2070000194 to X.L.);the University of Science and Technology of China Start-up Fund(KY9990000167 to Z.W.).; Shen Chromothripsis,a type of complex chromosomal rearrangement originally known as chromoanagenesis,has been a subject of extensive investigation due to its potential role in various diseases,particularly cancer.Chro...; 关键词：genomic stability DNA damage repair chromothripsis synthetic lethality cell division

Aurora B promotes the CENP-T–CENP-W interaction to guide accurate chromosome segregation in mitosis: 《Journal of Molecular Cell Biology》2024年第2期11-23,共13页Wei Liu Zhen Dou Chunyue Wang Gangyin Zhao Fengge Wu Chunli Wang Felix Aikhionbare Mingliang Ye Divine Mensah Sedzro Zhenye Yang Chuanhai Fu Zhikai Wang Xinjiao Gao Xuebiao Yao Xiaoyu Song Xing Liu; supported by the National Key Research and Development Program of China(2022YFA1303100,2022YFA0806800,2022YFA1302700,and 2017YFA0503600);the National Natural Science Foundation of China(32090040,92254302,92153302,92253301,22137007,32170733,and 31871359);the Ministry of Education(IRT_17R102);the Plans for Major Provincial Science&Technology Projects of Anhui Province(202303a0702003);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB19040000);the Fundamental Research Funds for the Central Universities(WK2070000066 and WK2070000194).; Accurate chromosome segregation in mitosis depends on kinetochores that connect centromeric chromatin to spindle microtubules.Centromeres are captured by individual microtubules via a kinetochore constitutive centrome...; 关键词：MITOSIS KINETOCHORE Aurora B CENP-T CENP-W PHOSPHORYLATION

Organization of microtubule plus-end dynamics by phase separation in mitosis: 《Journal of Molecular Cell Biology》2024年第2期24-35,共12页Fengrui Yang Mingrui Ding Xiaoyu Song Fang Chen Tongtong Yang Chunyue Wang Chengcheng Hu Qing Hu Yihan Yao Shihao Du Phil YYao Peng Xia Gregory Adams Jr Chuanhai Fu Shengqi Xiang Dan Liu Zhikai Wang Kai Yuan Xing Liu; supported by grants from the National Key Research and Development Program of China(2022YFA1303100,2022YFA0806800,2022YFA1302700,and 2017YFA0503600);the National Natural Science Foundation of China(32090040,92153302,92254302,92253305,31621002,21922706,92059102,and 92253301);the Plans for Major Provincial Science&Technology Projects of Anhui Province(202303a0702003),the Ministry of Education(IRT_17R102);the Fundamental Research Funds for the Central Universities(KB9100000007 and KB9100000013).; In eukaryotes,microtubule polymers are essential for cellular plasticity and fate decisions.End-binding(EB)proteins serve as scaffolds for orchestrating microtubule polymer dynamics and are essential for cellular dyna...; 关键词：phase separation MITOSIS microtubule dynamics EB1 ACETYLATION

PLK1 phosphorylation of ZW10 guides accurate chromosome segregation in mitosis: 《Journal of Molecular Cell Biology》2024年第2期47-62,共16页Sm Faysal Bellah Fangyuan Xiong Zhen Dou Fengrui Yang Xing Liu Xuebiao Yao Xinjiao Gao Liangyu Zhang; supported by grants from the Ministry of Science and Technology of China and the National Natural Science Foundation of China(2022YFA1303100,32090040,92254302,2022YFA0806800,91854203,31621002,2017YFA0503600,21922706,and 92153302 to X.L.;92053104 to X.G.);the Plans for Major Provincial Science&Technology Projects of Anhui Province(202303a0702003 to X.L.);the Ministry of Education(IRT_17R102 to X.L.);the Fundamental Research Funds for the Central Universities(KB9100000007 and KB9100000013 to X.L.)。; Stable transmission of genetic information during cell division requires faithful chromosome segregation.Mounting evidence has demonstrated that polo-like kinase 1(PLK1)dynamics at kinetochores control correct kinetoc...; 关键词：ZW10 PLK1 KINETOCHORE MITOSIS PHOSPHORYLATION

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