组蛋白H3的甲基化修饰与脂肪细胞分化关系的研究进展  

Research Progress in Relationship between Methylation Modification of Histone H3 and Adipocyte Differentiation

作　　者：武晓慧 杨帆 陈佳琪 刘婉莹 周秋安 魏婉丽 WU Xiaohui;YANG Fan;CHEN Jiaqi;LIU Wanying;ZHOU Qiu′an;WEI Wanli(Institute of Obesity and Metabolic Diseases,Xi′an Medical University,Xi′an 710021,China;Clinical Medical College,Xi′an Medical University,Xi′an 710021,China)

机构地区：[1]西安医学院肥胖与代谢病研究所,西安710021 [2]西安医学院临床医学院,西安710021

出　　处：《医学综述》2019年第17期3382-3388,共7页Medical Recapitulate

基　　金：陕西省教育厅项目(17JK0654);西安医学院配套基金项目(2018PT37);西安医学院高层次人才科研基金项目(2018RCYJ01)

摘　　要：超重和肥胖可以引起多种疾病,肥胖的形成与白色脂肪细胞内能量过度蓄积密切相关。人体内的棕色和米色脂肪细胞可以通过适应性产热消耗能量而减轻肥胖,这两类脂肪细胞的分化调控尚在研究中。表观遗传调控机制中的组蛋白H3的第4、9和27位氨基酸残基的甲基化和(或)去甲基化的一部分修饰酶及其催化产物与棕色和米色脂肪细胞分化及相关基因表达密切相关。组蛋白的甲基化修饰可能成为肥胖及其相关疾病的发病机制及治疗研究的新靶点。Overweight and obesity may cause a variety of diseases,and the formation of obesity is closely related to excessive energy accumulation in white adipocytes.Brown and beige adipocytes in the human body can relieve obesity by adaptive thermogenesis.The regulation of differentiation of these two types of adipocytes is still under study.Some methylation and/or demethylation modifying enzymes at the 4 th,9 th and 27 th amino acid residues of histone H3 and their catalytic products are closely related to the differentiation and expression of genes related to brown and beige adipocytes.Histone methylation may become a new target for the pathogenesis and treatment of obesity and its related diseases.

关 键 词：肥胖 白色脂肪细胞 棕色脂肪细胞 米色脂肪细胞 组蛋白H3 甲基化 

分 类 号：R364.2[医药卫生—病理学]