2-TURBT治疗NMIBC的疗效及对近期复发的影响  

Clinical efficacy of second transurethral resection of bladder tumors in the treatment of non-muscular invasive bladder cancer and its effect on recent recurrence

作　　者：李伟亮 陈瑛 颜伟 王宓 吴振启 LI Wei-liang;CHEN Ying;YAN Wei;WANG Mi;WU Zhen-qi(Department of Urology,Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University,Shanghai 201700,CHINA)

机构地区：[1]复旦大学附属中山医院青浦分院泌尿外科

出　　处：《海南医学》2019年第17期2268-2270,共3页Hainan Medical Journal

摘　　要：目的探讨二次经尿道膀胱肿瘤电切术(2-TURBT)治疗非肌层浸润性膀胱癌(NMIBC)的效果及对复发率的影响。方法选取2015年1月至2017年2月在复旦大学附属中山医院青浦分院泌尿外科治疗的90例NMIBC患者为研究对象,采用随机数表法将患者分为对照组和观察组,每组45例。对照组患者给予首次TURBT,观察组患者实施2-TURBT治疗,比较两组患者1年内的治疗效果及复发情况。结果观察组患者治疗后的复发率和进展率分别为13.33%、4.44%,均明显低于对照组的35.56%和22.22%,差异均有统计学意义(P<0.05);观察组患者的复发时间为(6.92±0.71)个月,明显长于对照组的(2.15±0.62)个月,原发部位复发率占2.22%,明显低于对照组的17.78%,差异均有统计学意义(P<0.05);观察组肿瘤分期Tis12例,Ta20例,T113例,对照组肿瘤分期Tis11例,Ta22例,T112例,观察组T1期肿瘤复发率(15.38%)明显低于对照组T1期肿瘤复发率(41.67%),差异有统计学意义(P<0.05),而观察组Tis及Ta期肿瘤复发率(16.67%、10.00%)与对照组Tis和Ta期肿瘤复发率(36.36、31.82%)比较差异均无统计学意义(P>0.05)。结论 2-TURBT治疗NMIBC可有效降低肿瘤复发,延缓病情进展,值得推广应用。Objective To investigate effect of second transurethral resection of bladder tumors(2-TURBT) in non-muscular invasive bladder cancer(NMIBC) and its influence on recurrence rate. Methods Ninety patients with NMIBC who were treated in Department of Urology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University from Jan. 2015 to Feb. 2017 were selected and divided into a control group and an observation group by random number table, with 45 patients in each group. The patients in the control group were treated with first TURBT, and the patients in observation group were treated with 2-TURBT. Therapeutic effect and rate of recurrence in one year were compared between the two groups. Results The recurrence rate and progress rate were 13.33%, 4.44% in observation group, respectively, significantly lower than 35.56% and 22.22% in control group(P<0.05). Time of recurrence was(6.92±0.71) months in observation group, significantly longer than(2.15±0.62) months in control group(P<0.05). The recurrence rate of primary site was 2.22% in observation group, significantly lower than 17.78% in control group(P<0.05). For tumor stage, there were 12 cases of Tis, 20 cases of Ta, and 13 cases of T1 in the observation group, versus 11 cases of Tis, 22 cases of Ta, and 12 cases of T1 in the control group;the recurrence rates of stage T11 tumors were 15.38%in the observation group, significantly lower than 41.67% in control group(P<0.05);the recurrence rates of stage Tisand Tatumors were 16.67% and 10.00% in the observation group versus 36.36% and 31.82% in control group(P>0.05).Conclusion 2-TURBT for treatment of NMIBC can effectively reduce recurrence of tumors and delay the progress of the disease, which is worthy of promotion and application.

关 键 词：二次经尿道膀胱肿瘤电切术 非肌层浸润性膀胱癌 复发 诊断 

分 类 号：R737.14[医药卫生—肿瘤]