不同基因类型人乳头状瘤病毒的高危因素分析  

Brief analysis on the risk factors of different gene types of human papillomavirus

作　　者：房玥 王晓东 王李利[1] 于素香[2] FANG Yue;WANG Xiao-dong;WANG Li-li;YU Su-xiang(Department of Obstetrics and Gynecology,Port Hospital of Hebei Port Group Co.,Ltd.Qinhuangdao 066002,China;Department of Pathology,Tangxian People′s Hospital, Hebei Province,Tangxian 072350,China)

机构地区：[1]河北港口集团有限公司港口医院妇产科,河北秦皇岛066002 [2]河北省唐县人民医院病理科,河北唐县072350

出　　处：《河北医科大学学报》2019年第9期1042-1046,共5页Journal of Hebei Medical University

摘　　要：目的探讨宫颈癌患者人乳头状瘤病毒(humman papilloma virus,HPV)不同基因类型的危险因素。方法采用导流杂交技术对322例宫颈癌患者进行HPV基因分型检测及流行病学问卷调查,寻找不同HPV基因类型的高危因素。结果322例患者共检测出23种HPV亚型,HPV感染率排在前3位的亚型从高到低依次为HPV18、HPV16和HPV53,分别占17.8%、15.0%、13.8%。不同年龄、性伴侣数、初次性生活年龄患者HPV18感染发生率差异有统计学意义(P<0.05);不同年龄、妊娠次数、初次性生活年龄患者HPV16感染发生率差异有统计学意义(P<0.05);不同年龄、妊娠次数患者HPV53感染发生率差异有统计学意义(P<0.05)。Logistic回归分析结果显示,年龄、性伴侣数是HPV18感染的危险因素,年龄、妊娠次数是HPV16感染的危险因素,妊娠次数是HPV53感染的危险因素(P<0.05)。结论女性年龄、性伴侣数是HPV18感染的危险因素,年龄、妊娠次数是HPV16感染的危险因素,妊娠次数是HPV53感染的危险因素,在日常宣教中应及时给予干预。Objective To analyze the risk factors of human papilloma virus(HPV)genotypes in patients with cervical cancer.Methods A total of 322 women diagnosed as cervical cancer were tested for HPV genotyping and investigated by epidemiological questionnaire.Meanwhile,the main influencing factors of different HPV genotypes were analyzed by multiple factor regression method to find out the high risk factors.Results Among 322 women surveyed,23 subtypes of HPV were detected.The top three subtypes of HPV infection rate were HPV18,HPV16 and HPV53,accounting for 17.8%,15.0%and 13.8%respectively.Univariate analysis of variance showed that the main risk factors affecting HPV18 infection were age,number of sexual partners and first intercourse(P<0.05).The main risk factors affecting HPV16 infection were age,number of pregnancies,age of first sexual life(P P<0.05).Age and number of pregnancies were risk factors for HPV53 infection(P<0.05).The results of binary logistic regression analysis showed that age and number of sexual partners were independent risk factors for HPV18 infection.Age and number of pregnancies were independent risk factors for HPV16 infection.Number of pregnancies is independent risk factors for HPV53 infection(P<0.05).Conclusion Age and number of sexual partners are related to HPV18 infection,age and number of pregnancies are related to HPV16,and number of pregnancies is related to HPV53 infection,so timely intervention should be given in daily education.

关 键 词：宫颈肿瘤 人乳头状瘤病毒 危险因素 

分 类 号：R737.33[医药卫生—肿瘤]