复方海藻粥对便秘模型小鼠通便功能的作用研究  

Laxative Effect of Seaweed Instant Porridge on the Constipated Model Mice

作　　者：白旭 胡波 王尚仪 范雨萌 宋淑亮 梁浩 吉爱国 BAI Xu;HU Bo;WANG Shang-yi;FAN Yu-meng;SONG Shu-liang;LIANG Hao;JI Ai-guo(Marine College, Shandong University(Weihai), Weihai 264209, Shandong, China;School of Pharmaceutical Sciences, Shandong University, Jinan 250012, Shandong, China)

机构地区：[1]山东大学(威海)海洋学院,山东威海264209 [2]山东大学药学院,山东济南250012

出　　处：《食品研究与开发》2019年第18期66-70,共5页Food Research and Development

摘　　要：探究一种复方海藻粥的润肠通便作用。根据药食同源的原则,将芋头、海带、无花果、低聚果糖、大枣、牛磺酸等原料按照一定比例配制成复方海藻粥。实验中小鼠随机分为空白对照组、阳性对照组、便秘模型对照组、高剂量实验组、中剂量实验组和低剂量实验组。连续给药7d后,测量小鼠的首粒黑便时间、6h内排便粒数、6h内排便质量及粪便含水量和小肠碳墨推进率。结果显示高、中剂量实验组与便秘模型组相比,6h内排便粒数、6h内排便质量及粪便含水量均显著增加(p<0.05),首粒黑便时间明显缩短(p<0.05)。高、中、低剂量实验组均明显提高了小鼠的小肠推进率(p<0.01),分别为16%、10%、6%。与阳性对照组相比,高剂量组首粒黑便时间、6h内排便粒数、6h内排便质量及粪便含水量无显著性差异。由此可知复方海藻粥可以促进胃肠道的蠕动,具有较为明显的润肠通便功能。The laxative effect of a compound seaweed instant porridge was studied.According to the principle of medicine and food homology, seaweed instant porridge was made with all kinds of edible taro, kelp, fig, oligosaccharide, jujube, taurine and so on in a certain proportion.Mice were randomly distributed as the blank control group, the positive control group, the constipated model group, the high-dose experimental group, the middle-dose experimental group, and the low-dose experimental group.After 7 days of continuous administration, the first black stool time, the number, weight, water content of defecation within 6 hours were determined, and the intestinal propulsive rate in each group were observed.The results showed that compared with the constipated model group, the high-dose and middle-dose experimental groups had significantly increased the number, weight and water content of defecation within 6 hours (p<0.05), and had shortened the first stool time significantly (p<0.05).And the high-dose, middle-dose and low-dose experimental group significantly increased the mice's intestinal propulsion rate (p<0.01), 16 %, 10 % and 6 % respectively.Additionally, there was no significant difference between the high dose group and the positive control group in the first stool time and number, weight, water content of defecation within 6 hours.Our data indicated that the seaweed instant porridge could promote motility of gastrointestinal tract and embellish aperient bowel function obviously.

关 键 词：海带粥 便秘 润肠 通便功能 小肠推进率 

分 类 号：TS201.4[轻工技术与工程—食品科学] R574.62[轻工技术与工程—食品科学与工程]