磷脂酰肌醇蛋白多糖-3和细胞角蛋白-19联合免疫组化检测在肝细胞肝癌诊断和鉴别诊断中的价值分析  

The value of combined application of phosphatidylinositol proteoglycan -3(GPC-3) and cytokeratin -19(CK-19) in the diagnosis and differential diagnosis of hepatocellular carcinoma

作　　者：李林[1] Li Lin(Bazhong Central Hospital, Bazhong,Sichuan 636000, China)

机构地区：[1]巴中市中心医院病理科,四川巴中636000

出　　处：《医药前沿》2019年第23期37-38,共2页Journal of Frontiers of Medicine

摘　　要：目的:探讨GPC-3和CK-19联合免疫组化检测对肝细胞肝癌诊断与鉴别诊断的应用价值.方法:以2014年7月—2018年8月巴中市中心医院病理科收治的100例肝肝癌患者作为研究对象,针对其实施GPC-3和CK-19联合免疫组化检测并分析结果.结果:在实施GPC-3免疫组化检测处理后,患者肝细胞肝癌、肝内胆管细胞癌、肝细胞肝癌伴随肝内胆管细胞癌的阳性检测率分别为84.8%、17.4%、100.0%,存在统计学差异(P<0.05).结论:GPC-3和CK-19联合免疫组化检测对肝细胞肝癌诊断与鉴别诊断应用价值较高.Objective Objective to explore the value of combined detection of GPC-3 and CK-19 in the diagnosis and differential diagnosis of hepatocellular carcinoma.Methods From July 2014 to August 2018,100 patients with liver cancer treated in the Department of Pathology of the Central Hospital of Bazhong City were studied. The combined immunohistochemical detection of GPC-3 and CK-19 was carried out and the results were analyzed.Results After GPC-3 immunohistochemical examination, the positive detection rates of HCC with intrahepatic cholangiocarcinoma and hepatocellular carcinoma were 84.8% and 17.4% and 100.0%, respectively There was statistical difference between the two groups.Conclusion The combination of GPC-3 and CK-19 is of great clinical value in the diagnosis and differential diagnosis of hepatocellular carcinoma, and the relevant methods are suitable for popularization.

关 键 词：肝细胞肝癌 磷脂酰肌醇蛋白多糖-3 细胞角蛋白-19 诊断价值 

分 类 号：R730.4[医药卫生—肿瘤]