Multifocal G1-G2 gastric neuroendocrine tumors:Differentiating between Type Ⅰ, Ⅱ and Ⅲ, a clinicopathologic review  

作　　者：Khaled Algashaamy Monica Garcia-Buitrago 

机构地区：[1]Department of Pathology and Laboratory Medicine, Jackson Memorial Hospital, University of Miami, Miller School of Medicine

出　　处：《World Journal of Clinical Cases》2019年第17期2413-2419,共7页世界临床病例杂志

摘　　要：Gastric neuroendocrine tumors (gNETs) are a rare entity that is increasing in incidence.Different pathophysiological processes can lead to the development of these tumors,appropriate histological analysis is necessary to differentiate between grade 1 (G1) and grade 2 (G2) tumors as this will impact the management of these patients based on their increased risk of lymph node and distant metastases.To provide a comprehensive clinicopathologic review of multifocal gastric neuroendocrine tumors,with particular emphasis on G1 and G2 tumors and differentiating between types I,II and II and risk stratification based upon immunohistochemical profile.This review is based on peer-reviewed literature and the authors’ experience.gNETs are a heterogenous group of tumors that is rising in incidence.These lesions while arise from the same cell type,they have different etiologies.Identifying the type of gNETs is a collective effort of clinical and pathologic correlation.The correct grading and staging of these lesions are of paramount significance,due its impact on patient management and prognosis.Gastric neuroendocrine tumors(g NETs) are a rare entity that is increasing in incidence. Different pathophysiological processes can lead to the development of these tumors, appropriate histological analysis is necessary to differentiate between grade 1(G1) and grade 2(G2) tumors as this will impact the management of these patients based on their increased risk of lymph node and distant metastases. To provide a comprehensive clinicopathologic review of multifocal gastric neuroendocrine tumors, with particular emphasis on G1 and G2 tumors and differentiating between types I, II and II and risk stratification based upon immunohistochemical profile. This review is based on peer-reviewed literature and the authors’ experience. g NETs are a heterogenous group of tumors that is rising in incidence. These lesions while arise from the same cell type, they have different etiologies. Identifying the type of g NETs is a collective effort of clinical and pathologic correlation. The correct grading and staging of these lesions are of paramount significance, due its impact on patient management and prognosis.

关 键 词：GASTRIC NEUROENDOCRINE tumors Enterochromaffin like cells HISTOPATHOLOGICAL features Immunohistochemistry Diagnosis Treatment 

分 类 号：R735.2[医药卫生—肿瘤]