Incidence of portal vein thrombosis after splenectomy and its influence on transjugular intrahepatic portosystemic shunt stent patency  

作　　者：Fang Dong Shi-Hua Luo Li-Juan Zheng Jian-Guo Chu He Huang Xue-Qiang Zhang Ke-Chun Yao 

机构地区：[1]Department of Vascular Surgery,Gansu Provincial Hospital,Lanzhou 730000,Gansu Province,China [2]Department of Radiology,Zhongnan Hospital of Wuhan University,Wuhan 430071,Hubei Province,China [3]Department of Gastroenterology,Gansu Provincial Hospital,Lanzhou 730000,Gansu Province,China [4]Department of Radiology,Air Force Medical Center of PLA,Beijing 100142,China [5]Department of Gastroenterology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,Hebei Province,China [6]Department of Ultrasound,Air Force Medical Center of PLA,Beijing 100142,China

出　　处：《World Journal of Clinical Cases》2019年第17期2450-2462,共13页世界临床病例杂志

摘　　要：BACKGROUND Transjugular intrahepatic portosystemic shunt (TIPS) is widely accepted as an alternative to surgery for management of complications of portal hypertension.TIPS has been used to treat portal vein thrombosis (PVT) in many centers since the 1990s.Although TIPS has good therapeutic effects on the formation of PVT,the effect of PVT on TIPS stenting has rarely been reported.Patients with splenectomy and pericardial devascu-larization have a high incidence of PVT,which can markedly affect TIPS stent patency and increase the risk of recurrent symptoms associated with shunt stenosis or occlusion.AIM To investigate the incidence of PVT after splenectomy and its influence on the patency rate of TIPS in patients with cirrhosis and portal hypertension.METHODS Four hundred and eighty-six patients with portal hypertension for refractory ascites and/or variceal bleeding who required TIPS placement between January 2010 and January 2016 were included in this retrospective analysis.Patients without prior splenectomy were defined as group A (n = 289) and those with prior splenectomy as group B (n = 197).The incidence of PVT before TIPS was compared between the two groups.After TIPS placement,primary patency rate was compared using Kaplan–Meier analysis at 3,6,9 and 12 mo,and 2 and 3 years.The clinical outcomes were analyzed.RESULTS Before TIPS procedure,the incidence of PVT in group A was lower than in group B (P = 0.003),and TIPS technical success rate in group A was higher than in group B (P = 0.016).The primary patency rate in group A tended to be higher than in group B at 3,6,9 and 12 mo,2 years and 3 years (P = 0.006,P = 0.011,P = 0.023,P = 0.032,P = 0.037 and P = 0.028,respectively).Recurrence of bleeding and ascites rate in group A was lower than in group B at 3 mo (P ≤ 0.001 and P = 0.001),6 mo (P = 0.003 and P = 0.005),9 mo (P = 0.005 and P = 0.012),12 mo (P = 0.008 and P = 0.024),2 years (P = 0.011 and P = 0.018) and 3 years (P = 0.016 and P = 0.017),respectively.During 3-years follow-up,the 1-,2- and 3-yeaBACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS) is widely accepted as an alternative to surgery for management of complications of portal hypertension.TIPS has been used to treat portal vein thrombosis(PVT) in many centers since the 1990 s. Although TIPS has good therapeutic effects on the formation of PVT,the effect of PVT on TIPS stenting has rarely been reported. Patients with splenectomy and pericardial devascu-larization have a high incidence of PVT,which can markedly affect TIPS stent patency and increase the risk of recurrent symptoms associated with shunt stenosis or occlusion.AIM To investigate the incidence of PVT after splenectomy and its influence on the patency rate of TIPS in patients with cirrhosis and portal hypertension.METHODS Four hundred and eighty-six patients with portal hypertension for refractory ascites and/or variceal bleeding who required TIPS placement between January2010 and January 2016 were included in this retrospective analysis. Patients without prior splenectomy were defined as group A(n = 289) and those with prior splenectomy as group B(n = 197). The incidence of PVT before TIPS was compared between the two groups. After TIPS placement, primary patency rate was compared using Kaplan–Meier analysis at 3, 6, 9 and 12 mo, and 2 and 3 years. The clinical outcomes were analyzed.RESULTS Before TIPS procedure, the incidence of PVT in group A was lower than in group B(P = 0.003), and TIPS technical success rate in group A was higher than in group B(P = 0.016). The primary patency rate in group A tended to be higher than in group B at 3, 6, 9 and 12 mo, 2 years and 3 years(P = 0.006, P = 0.011, P =0.023, P = 0.032, P = 0.037 and P = 0.028, respectively). Recurrence of bleeding and ascites rate in group A was lower than in group B at 3 mo(P ≤ 0.001 and P =0.001), 6 mo(P = 0.003 and P = 0.005), 9 mo(P = 0.005 and P = 0.012), 12 mo(P =0.008 and P = 0.024), 2 years(P = 0.011 and P = 0.018) and 3 years(P = 0.016 and P= 0.017), respectively. During 3-years follow-up, the 1-,

关 键 词：PORTAL hypertension Transjugular INTRAHEPATIC portosystemic shunt SPLENECTOMY PORTAL VEIN THROMBOSIS 

分 类 号：R[医药卫生]