非生物型人工肝在肝衰竭中的临床应用及进展  

Non-bioartificial liver in liver failure: Clinical application and research advances

作　　者：李爽[1] 刘静[1] 陈煜 LI Shuang;LIU Jing;CHEN Yu(Department of Hemodialysis, Center for Urology, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China)

机构地区：[1]首都医科大学附属北京佑安医院泌尿中心血液透析室,北京100069 [2]首都医科大学附属北京佑安医院疑难肝病及人工肝中心,肝衰竭与人工肝治疗研究北京市重点实验室,北京100069

出　　处：《临床肝胆病杂志》2019年第9期1909-1915,共7页Journal of Clinical Hepatology

基　　金：北京市科技计划课题(Z171100002217070);国家重点研发计划资助(2017YFA0103000);国家科技重大专项“艾滋病和病毒性肝炎等重大传染病防治”(2012ZX10002004-006,2017ZX10203201-005,2017ZX10201201,2017ZX10202203-006-001,2017ZX10302201-004-002);北京市医院管理局“登峰”人才培养计划基金资助项目(DFL20151601);北京市医院管理局临床医学发展专项经费资助(ZYLX201806)

摘　　要：人工肝是肝衰竭治疗的重要方法之一。目前临床上应用的非生物型人工肝类型多样,其原理各不相同,适应证也各有差别,同时患者病情的严重程度也千差万别,因此应根据患者病情特点,结合每一种人工肝的原理特点以及实际情况,制订个体化的治疗方案。介绍了目前临床常用的非生物型人工肝,并对其疗效进行重点讨论;探讨了如何根据肝衰竭患者不同的临床表现,选用恰当的人工肝治疗模式,以期为临床医生提供参考。Artificial liver is one of the most important methods for the treatment of liver failure.At present,there are many types of non-bioartificial liver used in clinical practice,with different mechanisms and indications,and the severity of the disease varies greatly among patients.Therefore,an individualized treatment regimen should be developed based on patients’ conditions,features of each type of artificial liver,and actual situation.This article introduces the non-bioartificial liver systems commonly used in clinical practice,discusses their therapeutic effects,and elaborates on how to choose the appropriate artificial liver according to the clinical manifestations of patients with liver failure,in order to provide a reference for clinicians.

关 键 词：肝 人工 肝功能衰竭 治疗学 精准医学 

分 类 号：R575.3[医药卫生—消化系统]