维生素K1治疗肝衰竭凝血功能障碍的研究进展  

Research advances in vitamin K1 in treatment of coagulopathy of liver failure

作　　者：熊壮[1] 刘扬扬[2] 霍少凯 宫嘉莲 金天一 王强[3] 王慧林 刘铁军[1] 冷炎[1] XIONG Zhuang;LIU Yangyang;HUO Shaokai(Department of Hepatology and Gastroenterology, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130000, China)

机构地区：[1]长春中医药大学附属医院肝脾胃病科,长春130000 [2]长春中医药大学附属医院内分泌科,长春130000 [3]长春中医药大学,长春130000

出　　处：《临床肝胆病杂志》2019年第9期2099-2103,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金项目(81804007);吉林省科技厅项目(20190304075YY);长春中医药大学培育基金项目(2018KJ04)

摘　　要：肝衰竭是多种因素引起的肝脏损害,而维生素K1治疗肝衰竭凝血功能障碍一直存在争议。回顾了各国肝衰竭诊疗指南以及维生素K1治疗肝病凝血功能障碍的文献,分析得出盲目应用维生素K1不能改善肝病患者凝血功能,但肝衰竭时维生素K缺乏且伴有凝血功能障碍时,应用维生素K1可能是必要的。另外,胆汁淤积状态可作为独立因素考虑,但有待于进一步验证。Liver failure is a type of liver injury caused by a variety of factors,and there are still controversies over the clinical effect of vitamin K1 in the treatment of coagulopathy of liver failure.This article reviews the guidelines for the diagnosis and treatment of liver failure in various countries and the articles on vitamin K1 in the treatment of coagulopathy of liver diseases.It is concluded that blind application of vitamin K1 cannot improve the coagulation function of patients with liver disease;however,vitamin K1 is necessary for patients with vitamin K deficiency and coagulopathy during liver failure.In addition,the state of cholestasis may be considered an independent factor,but further studies are needed for verification.

关 键 词：肝功能衰竭 维生素K1 血液凝固 

分 类 号：R575.3[医药卫生—消化系统]