颞叶癫痫患者认知功能障碍影响因素与事件相关电位的关系  

Correlation between influencing factors of cognitive dysfunction and event-related potentials in patients with temporal lobe epilepsy

作　　者：李陶乐 刘磊[1] 许虹[1] Li Taole;Liu Lei;Xu Hong(Neurology Department,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院神经内科,650032

出　　处：《中华行为医学与脑科学杂志》2019年第8期710-715,共6页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：云南省科技厅-昆明医科大学应用基础研究联合基金项目(2017FE467).

摘　　要：目的探索颞叶癫痫患者认知功能障碍的影响因素及其与事件相关电位的相关性。方法根据纳入排除标准选取60例颞叶癫痫患者,收集临床资料(包括发病年龄、病程、发作类型、发作频率和服用抗癫痫药物),对所有入组的患者均完善事件相关电位的检测(包括N1、P2、N2、P3波的潜伏期和P3波的波幅)进行综合分析。结果颞叶癫痫患者:N1、P2、N2、P3各波的潜伏期和P3波的波幅均值依次为(108.47±24.58)ms、(181.70±29.63)ms、(255.63±32.66)ms、(367.03±40.43)ms、(6.45±5.84)μV,发病年龄≤14岁组与发病年龄>14岁组ERPs(P3波的潜伏期)比较差异具有统计学意义(P<0.05);病程>5年组与病程≤5年组ERPs(N2波、P3波的潜伏期)比较差异具有统计学意义(P<0.05);存在全面性发作组与只有部分性发作组ERPs(P3波的波幅)比较差异具有统计学意义(P<0.05);发作次数>4次/月组与发作次数≤4次/月组ERPs(P3波的潜伏期)比较差异具有统计学意义(P<0.05);联合用药组与单药治疗组ERPs(N2波的潜伏期)比较差异具有统计学意义(P<0.05);颞叶癫痫的病程、联合用药是N2波的潜伏期的影响因素(P<0.05);颞叶癫痫发作频率、发病年龄及病程是P3波潜伏期的影响因素(P<0.05)。结论颞叶癫痫的发病年龄、病程、发作类型、发作频率及服用抗癫痫药物是患者认知功能障碍的重要影响因素,在事件相关电位中表现为对认知不同阶段产生不同方面的影响。Objective To explore the influencing factors of cognitive dysfunction in patients with temporal lobe epilepsy using event-related potential detection methods and to evaluate the correlation between them. Methods Sixty patients with temporal lobe epilepsy were enrolled according to the inclusion and exclusion criteria.Clinical data (including age of onset, duration of disease, type of seizure, frequency of episodes and anti-epileptic drugs) were collected.The determination of event-related potentials was improved for all patients enrolled.The latency of the N1, P2, N2, and P3 waves and the amplitude of the P3 wave are comprehensively analyzed. Results Patients with temporal lobe epilepsy: the average latency of N1, P2, N2 and P3 and the average amplitude of P3 wave were (108.47±24.58) ms,(181.70±29.63) ms,(255.63±32.66) ms,(367.03±40.43) ms and (6.45± 5.84)μV, respectively.ERPs (latency of P3 wave) of the age of onset ≤14 years old and the age of onset >14 years old group were statistically significant (P<0.05). ERPs (latency of N2 wave and P3 wave) of course>5 years group and disease course≤5 years group were statistically significant (P<0.05). There was significant difference in ERPs (P3 wave amplitude) between the general seizure group and the partial seizure group (P<0.05). ERPs (latency of P3 wave) frequency of seizures >4 times/month group and≤4 times/month group were statistically significant (P<0.05);ERPs (latency of N2 wave) of combination group and monotherapy group was statistically significant (P<0.05). The course of the temporal lobe epilepsy and medicine therapy of combination were impact factors of the latency of N2 wave (P<0.05). Temporal seizure frequency, age of onset and course of disease were impact factors of P3 wave (P<0.05). Conclusion Age of onset, the course of the temporal lobe epilepsy, the type of seizures, the frequency of seizures and the anti-epileptic drugs are important influencing factors of cognitive dysfunction in patients.In event-related potentials, they have diffe

关 键 词：颞叶癫痫 认知功能 事件相关电位 影响因素 

分 类 号：R742.1[医药卫生—神经病学与精神病学]