表没食子儿茶素没食子酸酯抗乳腺癌作用机制的研究进展  

Research progress on mechanism of epigallocatechin gallate in breast cancer

作　　者：余岳 葛洁[1,2,3,4] 曹旭晨 YU Yue;GE Jie;CAO Xu-chen(The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China;Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China;Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China;Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China)

机构地区：[1]天津医科大学肿瘤医院乳腺一科国家肿瘤临床医学研究中心,天津300060 [2]天津市“肿瘤防治”重点实验室,天津300060 [3]天津市恶性肿瘤临床医学研究中心,天津300060 [4]乳腺癌防治教育部重点实验室,天津300060

出　　处：《现代药物与临床》2019年第8期2567-2571,共5页Drugs & Clinic

基　　金：国家自然科学基金资助项目(81372843)

摘　　要：乳腺癌是女性最常见的恶性肿瘤,其发病率呈逐年上升趋势。表没食子儿茶素没食子酸酯(EGCG)是茶叶中的主要活性成分之一,具有抗氧化、抗炎症、保护心血管、预防糖尿病及抗肿瘤等功效。近年来,多项体内和体外研究表明EGCG通过抑制细胞增殖、血管生成、干性、侵袭转移及促进凋亡等方式抑制乳腺癌的发生发展。主要对EGCG抑制乳腺癌的分子机制进行综述,为乳腺癌的防治提供新的线索。Breast cancer is the most common malignant tumor among women, which showed rising trend year by year.Epigallocatechin gallate(EGCG) is the most abundant and bioactive polyphenol in green tea. It has been demonstrated to have many biological functions, including anti-oxidant, anti-inflammatory, cardiovascular protection, diabetes prevention, and anti-cancer.Recently, EGCG has been identified to suppress breast cancer tumorigenesis and progression through inhibition of cell proliferation,angiogenesis, cancer stem cell and metastasis, and induction of cell apoptosis. The molecular mechanism of EGCG in breast cancer is summarized in this paper, which provides clues for the prevention and treatment of breast cancer.

关 键 词：表没食子儿茶素没食子酸酯 乳腺癌 分子机制 

分 类 号：R979.1[医药卫生—药品]