胆囊切除及胆囊疾病与胆汁反流性胃炎的相关性分析  

Correlation between cholecystectomy or gallbladder disease and bile reflux gastritis

作　　者：肖刚[1] 刘艳梅 于宏[1] XIAO Gang;LIU Yanmei;YU Hong(The Second Department of General Surgery, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, P. R. China;Department of Rheumatology, The First Hospital of China Medical University, Shenyang 110004, P. R. China)

机构地区：[1]中国医科大学附属盛京医院第二普通外科,沈阳110004 [2]中国医科大学附属第一医院风湿免疫科,沈阳110001

出　　处：《中国普外基础与临床杂志》2019年第9期1072-1076,共5页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的研究胆囊切除和胆囊疾病与胆汁反流性胃炎之间的关系。方法回顾性收集2014年1月至2019年2月期间于中国医科大学附属盛京医院门诊及住院诊断为胆汁反流性胃炎的123例患者,同期收集诊断为非胆汁反流性胃炎的221例患者。将患者依据胆囊状态分为胆囊疾病、胆囊切除和胆囊无疾病3组,分析胆囊状态与胆汁反流性胃炎的关系。结果 123例胆汁反流性胃炎患者中存在胆囊切除22例(17.89%),胆囊疾病26例(21.14%);221例非胆汁反流性胃炎中存在胆囊切除7例(3.17%),胆囊疾病30例(13.57%)。胆汁反流组和非胆汁反流组的胆囊状态不同(χ~2=21.089,P<0.001)。胆囊状态和胆汁反流性胃炎的发生有关:相对于胆囊无疾病患者,胆囊切除和胆囊疾病患者的胆汁反流性胃炎发生风险较高(OR>1,P<0.012 5)。logistic多因素回归分析结果显示:胆囊切除、胆囊疾病及年龄是胆汁反流性胃炎的独立危险因素(P<0.05)。结论胆囊切除及胆囊疾病与胆汁反流性胃炎之间存在着关联性,胆囊切除和胆囊疾病可能是胆汁反流性胃炎的独立危险因素之一。Objective To study the relationship among cholecystectomy/gallbladder disease and bile reflux gastritis. Methods A retrospective collection of 123 patients with bile reflux gastritis who were diagnosed as outpatients and hospitalized from January 2014 to February 2019 in Shengjing Hospital Affiliated to China Medical University, and 221 patients with non-biliary reflux gastritis at the same period were collected. According to the gallbladder status, the patients were divided into three groups: gallbladder disease, cholecystectomy, and gallbladder disease-free group. The relationship between gallbladder status and bile reflux gastritis was analyzed. Results Among 123 patients with bile reflux gastritis, there were 22 cases(17.89%) with cholecystectomy and 26 cases(21.14%) with gallbladder disease;221 cases of non-biliary reflux gastritis with cholecystectomy in 7 cases(3.17%) and gallbladder disease in 30 cases(13.57%).Univariate analysis showed that the gallbladder status was different between the bile reflux gastritis group and the nonbiliary reflux gastritis group(χ~2=21.089, P<0.001). The study showed that the gallbladder status was related to the occurrence of bile reflux gastritis. In contrast, patients with cholecystectomy and gallbladder disease had a higher risk of occurrence than those with no gallbladder disease(OR>1, P<0.012 5). Independent risk factors were considered by logistic multivariate regression analysis, including cholecystectomy, gallbladder disease, and age(P<0.05). Conclusions There is a correlation between cholecystectomy/gallbladder disease and bile reflux gastritis. Cholecystectomy and gallbladder disease may be the independent risk factors for bile reflux gastritis.

关 键 词：胆汁反流性胃炎 胆囊切除 胆囊疾病 相关性 

分 类 号：R573.3[医药卫生—消化系统] R575.6[医药卫生—内科学]