轻型缺血性脑卒中患者认知功能障碍的相关因素分析  

Analysis of relative factors of the cognitive impairment of patients with mild ischemic stroke

作　　者：岳慧丽 秦鹏涛 付徐伟 李文战 司金超[2] YUE Huili;QIN Pengtao;FU Xuwei;LI Wenzhan;SI Jinchao(Department of Neurology,the 989th Hospital of PLA,Pingdingshan 467000,China;The Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450003,China)

机构地区：[1]中国人民解放军联勤保障部队第989医院神经内科,河南平顶山467000 [2]郑州大学第二附属医院,河南郑州450003

出　　处：《中国实用神经疾病杂志》2019年第13期1435-1441,共7页Chinese Journal of Practical Nervous Diseases

基　　金：河南省杰出青年基金(编号:74100510001)

摘　　要：目的探讨轻型缺血性脑卒中患者认知功能障碍(post-stroke cognitive impairment,PSCI)的发生率和相关危险因素.方法选取2017-09-2018-09就诊于中国人民解放军联勤保障部队第989医院神经内科的首发轻型缺血性脑卒中患者共120例,采用MMSE评分、MOCA评分将其分为PSCI组57例和N-PSCI组63例,对2组一般资料及相关影响因素进行单因素分析,有显著差异的指标进行多因素Logistic回归确定其影响程度.结果轻型缺血性脑卒中患者PSCI的发生率高达47.5%,其中以延迟回忆和视空间及执行功能最为明显;单因素分析表明,2组年龄、高血压、静止性脑梗死、Fazekas评分差异有统计学意义(P<0.05);多因素Logistic回归分析提示,高血压、静止性脑梗死为PSCI的独立危险因素(P<0.05).结论轻型缺血性脑卒中患者PSCI的发生率较高,高血压、静止性脑梗死可能是其独立的危险因素.Objective To explore the prevalence and predictors of post stroke cognitive impairment in patients with mild ischemic stroke. Methods 120 patients with first ever mild ischemic stroke from September 2017 to September 2018 were selected.All the patients were divided into PSCI group (57 cases) and N-PSCI group (63 cases) according to the score of MMSE and MOCA.The general information and related factors between two groups were analyzed by single factor analysis.The significantly different factors were adopted to undergo Logistic regression analysis to determine the degree of their effects. Results The prevalence of PSCI in patients with mild ischemic stroke was 47.5%,especially in delayed recall,visuospatial and executive function.Univariate analysis showed that age,hypertension,silent cerebral infarcts,fazekas score had statistical significance between two groups ( P <0.05).Multivariate logistic analysis indicated that hypertension and silent cerebral infarcts were independent risk factors for PSCI ( P <0.05). Conclusions Patients with mild ischemic stroke have higher PSCI,meanwhile,hypertension and Silent cerebral infarction may be independent risk predictors for PSCI.

关 键 词：缺血性脑卒中 轻型卒中 认知功能障碍 高血压 静止性脑梗死 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]