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作 者:宋魏 孙淼淼 张建波 于庆凯 SONG Wei;SUN Miaomiao;ZHANG Jianbo;YU Qingkai(Department of Pathology,Affiliated Tumor Hospital,Zhengzhou University,Zhengzhou 450000,China)
机构地区:[1]郑州大学附属肿瘤医院病理科
出 处:《中国实用神经疾病杂志》2019年第13期1448-1453,共6页Chinese Journal of Practical Nervous Diseases
基 金:河南省医学科技攻关计划项目(编号:2018020482)
摘 要:目的探讨MDM2、Bcl-2、雄激素受体(AR)的表达与脑膜瘤病理类型的关系,为脑膜瘤临床诊疗提供参考依据.方法选取郑州大学附属肿瘤医院病理科2012-02—2014-06收治的90例已经证实的脑膜瘤患者标本作为研究对象,将90例蜡块每份作3张切片,通过免疫组化染色法检测MDM2、Bcl-2、AR的表达.结果 MDM2的表达呈现一定的梯度效果,其中Ⅲ级脑膜瘤、Ⅱ级脑膜瘤、Ⅰ级脑膜瘤阳性表达率分别为10.0%、54.5%、56.9%,对比差异无统计学意义(P>0.05);Bcl-2的表达也呈现一定的梯度,Ⅲ级脑膜瘤、Ⅱ级脑膜瘤、Ⅰ级脑膜瘤阳性表达率分别为40.0%、45.5%、51.7%,对比差异无统计学意义(P>0.05);AR的表达在不同病理类型脑膜瘤中的阳性表达率梯度最为明显,Ⅲ级脑膜瘤、Ⅱ级脑膜瘤、Ⅰ级脑膜瘤阳性表达率分别为70.0%、54.5%、29.3%,经Chi-Square检验分析其对比差异具有统计学意义(P<0.05).结论 AR表达与脑膜瘤的病理级别分型明显相关,临床实践中要意识到其对瘤细胞增殖作用的重要性,可将其作为预后效果评估指标.Objective To investigate the relationship between the expression of MDM2,Bcl-2 and AR and the pathological types of meningioma,and to provide reference for the clinical diagnosis and treatment of meningioma. Methods A total of 90 confirmed cases of meningioma patients admitted to our department of pathology from February 2012 to June 2014 were selected as subjects.90 pieces of wax pieces were made into 3 sections,and MDM2,Bcl-2 and the expression of ARwere detected by immunohistochemical staining. Results The expression of MDM2 showed a certain gradient effect.The positive expression rates of grade Ⅲ meningioma,grade Ⅱ meningioma and grade I meningioma were 10.0%,54.5% and 56.9%,respectively.There was no significant difference between the two groups ( P >0.05).The expression of Bcl-2 also showed a certain gradient.The positive expression rates of grade Ⅲ meningioma,grade Ⅱ meningioma and grade I meningioma were 40.0%,45.5% and 51.7%,respectively.There was no significant difference between the two groups ( P >0.05).The expression of AR was the most obvious in the different pathological types of meningioma.The positive expression rates of grade Ⅲ meningioma,grade Ⅱ meningioma and grade I meningioma were 70.0%,54.5%,29.3%,respectively.Chi Square test analysis showed statistically significant differences ( P <0.05). Conclusion The expression of AR is closely related to the pathological grade of meningiomas.It is important to understand the importance of tumor cell proliferation in clinical practice.It can be used as an indicator for evaluating prognosis.
关 键 词:MDM2、Bcl-2 雄激素受体 脑膜瘤 免疫组化染色法 病理级别
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