颅内动脉狭窄斑块高分辨MRI影像学特征及其危险因素分析  

Imaging characteristics of HR-MRI and risk factors for intracranial artery stenosis plaques

作　　者：张锋[1] 徐英进[2] 边静[3] 王旭光[1] 辛伟凡 李博 ZHANG Feng;XU Yingjin;BIAN Jing;WANG Xuguang;XIN Weifan;LI Bo(Department of Radiology,the Sixth People's Hospital of Hebei,Baoding 071000,China;CT/MRI Room ithe Affiliated Hospital of Hebei University,Baoding 071000,China;Department of Medicine,Hebei University,Baoding 071002,China)

机构地区：[1]河北省第六人民医院放射科,河北保定071000 [2]河北大学附属医院CT/MRI室,河北保定071000 [3]河北大学医学部,河北保定071002

出　　处：《实用放射学杂志》2019年第9期1395-1398,共4页Journal of Practical Radiology

摘　　要：目的分析颅内动脉狭窄斑块高分辨磁共振成像(HR-MRI)影像学特征及其危险因素。方法选取90例缺血性脑卒中患者作为研究对象,均予以颅内动脉HR-MRI检查,按照斑块与缺血区域内责任动脉关系差异分为非责任动脉斑块组与责任动脉斑块组,比较2组HR-MRI检查指标;按照斑块强化程度差异分为非明显强化组与明显强化组,比较2组一般资料,并分析斑块强化危险因素。结果非责任动脉斑块组最小管腔面积明显大于责任动脉斑块组(P<0.05),管腔狭窄程度<50%、无/轻度强化、大脑前动脉与后动脉斑块所占比例明显高于责任动脉斑块组(P<0.05);非明显强化组低密度脂蛋白胆固醇(LDL-C)水平与LDL-C/高密度脂蛋白胆固醇(HDL-C)值显著低于明显强化组(P<0.05);LDL-C水平、LDL-C/HDL-C值升高为颅内动脉狭窄斑块强化危险因素(P<0.05)。结论 HR-MRI能清晰显示缺血性脑卒中患者非责任斑块与责任斑块管腔狭窄、斑块形态及斑块强化程度差异,斑块强化程度可以反映斑块稳定性,LDL-C水平与LDL-C/HDL-C值升高为颅内动脉狭窄斑块危险因素。Objective To analyze the imaging characteristics of high resolution magnetic resonance imaging ( HR-MRI) and risk factors for intracranial artery stenosis plaques.Methods 90 patients with ischemic stroke were selected as the subjects, and all of them were examined by intracranial arterial HR-MRI.They were divided into the non-offending arterial plaque group and the offending arterial plaque group according to the difference in the relationship between the plaque and the offending artery in the ischemic region.The examination indexes of HR-MRI were compared between the 2 groups.According to the difference in the degree of plaque enhancement, the subjects were divided into the non obvious enhancement group and the obvious enhancement group, and the general data were compared between the 2 groups.The risk for plaque enhancement were analyzed. Results The area of the smallest lumen in the non-offending arterial plaque group was significantly larger than that in the offending arterial plaque group (P<0.05),and the ratios of lumen stenosis degree lower than 50%, no/mild enhancement, anterior cerebral artery and posterior artery plaques were significantly higher than those in the offending arterial plaque group (P<0.05).The level of LDL-C and LDL-C/HDL-C in the non obvious enhancement group were significantly lower than those in the obvious enhancement group (P<0.05).The increased level of LDL-C and LDL-C/HDL-C were risk factors for enhancement of intracranial artery stenosis plaques (P <0.05 ).Conclusion HR-MRI can clearly show the differences in plaque lumen stenosis,shape of plaques and enhancement degree of plaques between non-offending arterial plaque and offending arterial plaque in patients with ischemic stroke.The degree of plaque enhancement can reflect the stability of plaque,and the increased level of LDL-C and LDL-C/HDL-C are risk factors for intracranial artery stenosis plaque.

关 键 词：关键词:颅内动脉 狭窄斑块 高分辨磁共振成像 影像学特征 危险因素 

分 类 号：R743[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]