p53、p16、CK5/6、VEGF和Ki-67在乳腺癌组织中的表达及临床意义  

Expressions and clinical significance of p53,p16,CK5/6,VEGF and Ki-67 in breast cancer tissues

作　　者：许立生[1] 王水 赵志泓[1] 王坤[1] XU Lishen;WANG Shui;ZHAO Zhihong(Department of Thyroid and Breast Surgery, Affiliated Hospital, Jiangsu University, Zhenjiang 212001, CHINA)

机构地区：[1]江苏大学附属医院甲乳外科,江苏镇江212001 [2]南京医科大学第一附属医院乳腺中心

出　　处：《江苏医药》2019年第8期770-773,F0002,共5页Jiangsu Medical Journal

基　　金：江苏大学附属医院科技项目(jdfyRC2018007)

摘　　要：目的探讨p53、p16、细胞角蛋白5/6(CK5/6)、血管内皮生长因子(VEGF)和Ki-67在乳腺癌组织中的表达及临床意义。方法采用免疫组化法检测139例乳腺癌及癌旁正常组织中p53、p16、CK5/6、VEGF和Ki-67的表达,分析其与患者临床特征及预后的关系。结果乳腺癌组织中,p53、CK5/6、VEGF和Ki-67的阳性表达率高于癌旁正常组织,p16的阳性表达率低于癌旁正常组织(P<0.05)。p53的表达与TNM分期、组织学分级和淋巴结转移有关(P<0.05);p16、VEGF的表达与病理类型和淋巴结转移有关(P<0.05);CK5/6的表达与年龄、组织学分级和淋巴结转移有关(P<0.05);Ki-67的表达与TNM分期和淋巴结转移有关(P<0.05)。p53、CK5/6、VEGF和Ki-67阳性表达患者的3年总生存率低于阴性表达患者,p16阳性表达患者的3年总生存率高于阴性表达患者(P<0.05)。结论 p53、p16、CK5/6、VEGF和Ki-67的表达与乳腺癌的浸润、转移及预后密切相关,可作为乳腺癌诊断及预后评估的重要指标。Objective To investigate the expressions and clinical significance of p53,p16,cytokeratin(CK)5/6,vascular endothelial growth factor(VEGF) and Ki-67 in breast cancer tissues.Methods The expressions of p53, p16, CK5/6,VEGF and Ki-67 were detected in breast cancer tissues and tumor-adjacent normal tissues in 139 patients with breast cancer.The relationship of the expressions of p53,p16,CK5/6,VEGF and Ki-67 with the clinical characteristics and prognosis was analyzed.Results The positive expression rates of p53,CK5/6,VEGF and Ki-67 in breast cancer tissues were higher,but p16 expression rate was lower,than those in tumor-adjacent normal tissues(P<0.05).The expression of p53 was closely related with TNM stage,histological grade and lymph node metastasis(P<0.05).The expressions of p16 and VEGF were closely related with pathological type and lymph node metastasis(P<0.05).CK5/6 expression was closely related with age,histological grade and lymph node metastasis(P<0.05).Ki-67 expression was closely related with TNM stage and lymph node metastasis(P<0.05).The 3-year survival rates in the patients with positive expressions of p53,CK5/6,VEGF and Ki-67 were lower than those in the patients with negative expressions(P<0.05).The 3-year survival rate in the patients with positive expression of p16 was higher than that in the patients with negative expression(P<0.05).Conclusion The expressions of p53,p16,CK5/6,VEGF and Ki-67 are closely related to the invasion,metastasis and prognosis of breast cancer,which can be used as the indicators for the diagnosis and prognosis evaluation in the patients with breast cancer.

关 键 词：乳腺癌 P53 P16 细胞角蛋白 血管内皮生长因子 KI-67 

分 类 号：R737[医药卫生—肿瘤]