前列腺癌中与雄激素受体功能相关的长链非编码RNA研究进展  

Long non-coding RNAs related to androgen receptor function in prostate cancer: Advances in studies

作　　者：王梦 应杰 张蒙 梁朝朝[1] WANG Meng;YING Jie;ZHANG Meng;LIANG Chao-zhao(Department of Urology,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China)

机构地区：[1]安徽医科大学第一附属医院泌尿外科

出　　处：《中华男科学杂志》2019年第8期739-743,共5页National Journal of Andrology

摘　　要：长链非编码RNA(LncRNA)是一种长度超过200个左右核苷酸的非编码RNA,曾被认为是DNA的“转录噪音”,但现已证实其广泛参与基因表达调控,并在细胞增殖、分化、凋亡以及肿瘤的发生、进展过程中起关键作用。目前已有系列lncRNA被证实参与调控前列腺癌进展,包括癌细胞从激素敏感性到去势抵抗性的转化过程等。雄激素受体(AR)是目前临床实践和科学研究共同证实的在前列腺癌发生和进展过程中最为关键作用的调控因子,而当前研究亦证实lncRNA可通过影响AR通路,继而影响前列腺癌的进展和耐药。故此,厘清AR和lncRNA之间的互作关联有助于了解前列腺癌发病或进展的生物学机制,并为前列腺癌的治疗提供一定思路。Long non-coding RNAs (lncRNA) are a cluster of non-coding RNAs with a length of more than 200 nucleotides, which,formerly considered as " transcriptional noise" of DNA,have now been proved to be widely involved in the regulation of gene expressions and play pivotal roles in the proliferation,differentiation and apoptosis of cells and the development and progression of tumors.Recent studies show that a series of lncRNAs participate in the regulation of the progression of prostate cancer,including the transition of the cancer cells from hormone-sensitive to castration-resistant.Androgen receptor (AR) has been proved by clinicians and researchers to be a key regulating factor in the initiation and progression of prostate cancer.Abundant evidence shows that lncRNAs can influence the AR signaling pathway and thus the progression and drug resistance of prostate cancer.Therefore,a clarification of the interaction between AR and lncRNA will help us better understand the biological mechanisms of tumorigenesis and provide some ideas for the treatment of prostate cancer.

关 键 词：长链非编码RNA 前列腺癌 雄激素受体 

分 类 号：R737.25[医药卫生—肿瘤]