石杉碱甲联合注射用鼠神经生长因子对老年痴呆MMSE评分及日常生活能力的影响  

Effect of Huperzine A Combined with Mouse Nerve Growth Factor for Injection on the MMSE Score and Activity of Daily Life of Senile Patients with Dementia

作　　者：肖珊 张策 杨瑞 陈星 拓珍 张丽云[1] XIAO Shan;ZHANG Ce;YANG Rui;CHEN Xing;TUO Zhen;ZHANG Li-yun(Neurology Department, Xi'an Gaoxin Hospital,Xi'an,Shaanxi,710075,China;Neurology Department, The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi,710061,China)

机构地区：[1]西安高新医院神经内二科,陕西西安710075 [2]西安交通大学第一附属医院神经内科,陕西西安710061

出　　处：《现代生物医学进展》2019年第15期2945-2948,共4页Progress in Modern Biomedicine

基　　金：国家临床重点专科建设项目([2010]305)

摘　　要：目的:研究石杉碱甲联合注射用鼠神经生长因子对老年痴呆简易智力状态检查量表(MMSE)及日常生活能力量表(ADL)评分的影响。方法:选择2015年6月~2018年6月我院收治的98例老年痴呆患者,随机分为两组。对照组口服石杉碱甲,起始给药剂量为每次100μg,每天2次,第2周给药剂量调整为每次150μg,每天2次,维持用量。观察组联合静脉滴注鼠神经生长因子,每次20μg,每天1次。比较两组治疗前后ADL和MMSE评分、血清白细胞介素(IL)-1β、C-反应蛋白(CRP)、IL-6、肿瘤坏死因子-α(TNF-α)水平的变化。结果:治疗后,观察组的总有效率为87.75%(43/49),明显高于对照组[69.39%(34/49)](P<0.05);两组治疗后的ADL和MMSE评分及血清IL-1β、CRP、IL-6和TNF-α水平均较治疗前明显降低(P<0.05),且观察组以上指标均明显低于对照组(P<0.05)。结论:与单用石杉碱甲相比,注射用鼠神经生长因子联合石杉碱甲可更有效改善其日常生活能力和认知功能,且能显著降低血清炎症因子水平。Objective: To investigate the effect of Huperzine A combined with mouse nerve growth factor for injection on the MMSE score and activity of daily life of cenile patients with dementi. Methods: 98 cases of senile patients withdementia who were treated in our hospital from June 2015 to June 2018 were selected and randomly divided into two groups. The control group was given Huperzine A orally. The initial dosage was 100 μg each time, twice a day. The dosage of Huperzine A was adjusted to 150 μg each time at the 2 nd week, twice a day, and the dosage was maintained. The observation group was given intravenous drip of mouse nerve growth factor, 20 g each time, 1 times a day on the basis of control group. The changes of ADL and MMSE scores, serum levels of interleukin(IL)-1 beta, C-reactive protein(CRP), IL-6 and tumor necrosis factor-alpha(TNF-alpha) were compared between the two groups before and after treatment. Results: After treatment, the total effective rate of observation group was 87.75%(43/49), which was significantly higher than that of the control group [69.39%(34/49)](P<0.05). After treatment, the ADL and MMSE scores, serum IL-1β, CRP, IL-6 and TNF-α levels in both groups were significantly lower than those before treatment(P<0.05), and the above indexes in the observation group were significantly lower than those in the control group(P<0.05). Conclusion: Compared with Huperzine A alone, Huperzine A combined with mouse nerve growth factor can more effectively improve the daily living ability, cognitive function of mice and reduce the level of serum inflammatory factors.

关 键 词：石杉碱甲 鼠神经生长因子 老年痴呆 日常生活能力 

分 类 号：R749.16[医药卫生—神经病学与精神病学]