利培酮联合阿立哌唑对慢性精神分裂症患者认知功能及社会功能的影响  

Effects of Risperidone Combined with Aripiprazole on Cognitive Function and Social Function in Patients with Chronic Schizophrenia

作　　者：周波 冯杰[2] ZHOU Bo;FENG Jie(Pangang Group General Hospital,Sichuan Panzhihua 617000)

机构地区：[1]攀钢集团总医院,四川攀枝花617000 [2]攀枝花市第三人民医院,四川攀枝花617000

出　　处：《医学临床研究》2019年第8期1533-1535,共3页Journal of Clinical Research

摘　　要：【目的】探讨利培酮联合阿立哌唑在慢性精神分裂症患者中的临床效果及对患者认知功能、社会功能的影响。【方法】选择2016年6月至2018年5月本院收治的54例慢性精神分裂症患者,根据用药方法的不同将其分为观察组(利培酮+阿立哌唑)和对照组(利培酮),每组各27例。治疗3个月后比较两组认知功能、社会功能及药物安全性。【结果】治疗后3个月,两组患者韦氏记忆量表(WMS)中再认、图片、联想及背数记忆评分均高于治疗前,且观察组均高于对照组,差异有统计学意义(P<0.05)。治疗后3个月,两组患者社会缺陷筛查量表(SDSS)中职业功能、父母智能、婚姻智能、家内活动、社会活动、社会退缩、自我照顾、责任心、关心社会及家庭智能评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组治疗期间血压降低、嗜睡、心电图异常、恶心呕吐及锥体外系反应发生率比较,差异均无统计学意义(P>0.05)。【结论】利培酮联合阿立哌唑治疗慢性精神分裂症能有效改善患者认知功能及社会功能,且药物不良反应少,值得推广应用。【Objective】To investigate the clinical effects of risperidone combined with aripiprazole in patients with chronic schizophrenia and its effects on cognitive function and social function.【Methods】Fifty-four patients with chronic schizophrenia admitted to our hospital from June 2016 to May 2018 were divided into observation group (risperidone + aripiprazole) and control group (risperidone),27 cases in each group.After 3 months of treatment,the cognitive function,social function and drug safety were compared between the two groups.【Results】3 months after treatment,the scores of recognition,picture,association and back memory in Wechner memory scale (WMS) in the two groups were higher than those before treatment,and the scores in the observation group were higher than those in the control group,the difference was statistically significant (P<0.05).Three months after treatment,the scores of occupational function,parental intelligence,marriage intelligence,family activity,social withdrawal,self-care,responsibility,care and family intelligence in the social defect screening scale (SDSS) of the two groups were lower than those before treatment,and the observation group was lower than the control group,the difference was statistically significant (P<0.05).There was no significant difference in the incidence of blood pressure decrease,lethargy,abnormal electrocardiogram,nausea,vomiting and extrapyramidal reaction between the two groups (P>0.05).【Conclusion】Risperidone combined with aripiprazole in the treatment of chronic schizophrenia can effectively improve the cognitive and social functions of patients with less adverse drug reactions,which is worthy of promotion and application.

关 键 词：抗精神病药/治疗应用 哌嗪类/治疗应用 精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]