Solid-state nanopores for ion and small molecule analysis  

作　　者：Qi Zhang Yue Cheng Peisheng Cao Zhiyuan Gu 

机构地区：[1]Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University

出　　处：《Chinese Chemical Letters》2019年第9期1607-1617,共11页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China (No. 21505076);the Young Elite Scholar Support (YESS) Program from China Association for Science and Technology (No. YESS20150009);the Program of Jiangsu Specially-Appointed Professor, the Natural Science Foundation of Jiangsu Province of China (No. BK20150967);the Innovation Team Program of Jiangsu Province of China;the Priority Academic Program Development of Jiangsu Higher Education Institutions

摘　　要：Solid-state nanopore in analytical chemistry has developed rapidly in the 1990s and it is proved to be a versatile new tool for bioanalytical chemistry. The research field of solid-state nanopore starts from mimicking the biological nanopore in living cells. Understanding the transport mechanism of biological nanopore in vivo is a big challenge because of the experimental difficulty, so it is essential to establish the basic research of artificial nanopores in vitro especially for the analysis of ions and small molecules. The performance of solid-state nanopores could be evaluated by monitoring currents when ions and molecules passed through. The comparison of the two types of nanopores based on current-derived information can reveal the principle of biological nanopores, while the solid-state nanopores are applied into practical bioanalysis. In this review, we focus on the researches of the solid-state nanopores in the fabrication process and in the analysis of ions and small molecules. Fabrication methods of nanopores,ion transport mechanism, small molecule analysis and theoretical studies are discussed in detail.Solid-state nanopore in analytical chemistry has developed rapidly in the 1990s and it is proved to be a versatile new tool for bioanalytical chemistry. The research field of solid-state nanopore starts from mimicking the biological nanopore in living cells. Understanding the transport mechanism of biological nanopore in vivo is a big challenge because of the experimental difficulty, so it is essential to establish the basic research of artificial nanopores in vitro especially for the analysis of ions and small molecules. The performance of solid-state nanopores could be evaluated by monitoring currents when ions and molecules passed through. The comparison of the two types of nanopores based on current-derived information can reveal the principle of biological nanopores, while the solid-state nanopores are applied into practical bioanalysis. In this review, we focus on the researches of the solid-state nanopores in the fabrication process and in the analysis of ions and small molecules. Fabrication methods of nanopores,ion transport mechanism, small molecule analysis and theoretical studies are discussed in detail.

关 键 词：Solid-state NANOPORES Single NANOPORE ION Small molecule Nonlinear CURRENT-VOLTAGE curves IONIC current RECTIFICATION 

分 类 号：O6[理学—化学]