腹盆腔播散性肿瘤热灌注化疗与单纯灌注化疗联合体外高频热疗临床评价分析  

Clinical Evaluation of Hyperthermia Combined with Perfusion Chemotherapy Combined with Perfusion Chemotherapy in Abdominal and Pelvic Cavity

作　　者：范鑫 陈毅德 冯水土 郑志高 FAN Xin;CHEN Yi-de;FENG Shui-tu;ZHENG Zhi-gao(Department of Oncology,Haicang Hospital of Xiamen,Xiamen,Fujian Province,361021 China)

机构地区：[1]厦门市海沧医院肿瘤科

出　　处：《中外医疗》2019年第23期44-46,共3页China & Foreign Medical Treatment

摘　　要：目的探讨腹盆腔恶性肿瘤患者应用热灌注化疗与单纯灌注化疗联合高频热疗两种治疗方法的不同临床疗效。方法方便选取2017年2月-2018年2月该院收治的48例复发转移晚期腹盆腔内肿瘤患者为研究对象,随机将其分为对照组24例和观察组24例。对照组采用单纯灌注化疗联合高频热疗,观察组采用热灌注化疗。对比两组患者的临床疗效、生活质量改善和不良反应情况。结果两组患者的近期疗效比较,观察组患者的总有效率70.83%显著优于对照组患者总有效率33.33%,差异有统计学意义(χ^2=8.426,P=0.000)。两组患者治疗前的QOL评分例数差异无统计学意义(t=0.041,P=0.613)。治疗结束后,两组患者的生活质量均有所改善,且观察组的改善情况更好,相比差异有统计学意义(t=6.243,P=0.013)。两组患者治疗中的不良反应比较,在骨髓抑制、肝功能异常、胃肠道反应、腹痛、腹泻、肠粘连等不良反应的发生率上差异无统计学意义(P>0.05)。结论对腹盆腔恶性肿瘤患者应用热灌注化疗与单纯灌注化疗联合高频热疗相比,热灌注化疗的临床疗效更具优势,在生活质量改善上也更显著,但是两种方法治疗的毒副反应无显著差异,不会增加患者的不良反应率。Objective To investigate the clinical effects of two treatments: hyperthermic perfusion chemotherapy combined with perfusion chemotherapy combined with high-frequency hyperthermia in patients with abdominal and pelvic malignant tumors.Methods A total of 48 patients with advanced recurrent pelvic tumors who underwent recurrence and metastasis from February 2017 to February 2018 were convenient enrolled in the study.They were randomly divided into control group (n=24) and observation group (n=24).The control group was treated with simple perfusion chemotherapy combined with high-frequency hyperthermia,and the observation group was treated with hyperperfusion chemotherapy.The clinical efficacy,quality of life improvement and side effects of the two groups were compared.Results Compared with the short-term efficacy of the two groups,the total effective rate of the observation group was 70.83%,which was significantly better than the total effective rate of the control group (33.33%).The difference was statistically significant (χ^2=8.426,P=0.000).There were no statistically significant differences in QOL scores between the two groups before treatment (t=0.041,P=0.613).After the end of treatment,the case of quality of life of both groups improved,and the improvement of the observation group was better,the difference was statistically significant(t=6.243,P=0.013).There was no statistically significant difference in the incidence of adverse reactions such as myelosuppression,abnormal liver function,gastrointestinal reactions,abdominal pain,diarrhea,and intestinal adhesions between the two groups(P>0.05).Conclusion Compared with high-frequency hyperthermia in patients with abdominal and pelvic malignant tumors,the clinical efficacy of hyperthermic perfusion chemotherapy is more advantageous,and the quality of life is also more significant.There was no significant difference in response and it did not increase the patient's adverse reaction rate.

关 键 词：热灌注化疗 腹盆腔恶性肿瘤 单纯灌注化疗联合高频热疗 

分 类 号：R730[医药卫生—肿瘤]