3, 4-seco-Labdane diterpenoids from the leaves of Callicarpa nudiflora with anti-inflammatory effects  

作　　者：WANG Hong-Gang LUO Fu-Kang LEI Xiang YAO Yun-Da LIAO Guo-Chao LIU Zhong-Qiu JIANG Zhi-Hong ZHOU Hua WU Peng 

机构地区：[1]Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of China,International Institute for Translational Chinese Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006,China [2]School of Translational Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China [3]State Key Laboratory of Quality Research in Chinese Medicine,Macao University of Science and Technology,Macao 999078,China

出　　处：《Chinese Journal of Natural Medicines》2019年第9期707-712,共6页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.81503224);Guangdong Key Laboratory for translational Cancer research of Chinese Medicine(No.2018B030322011);Department of education of Guangdong Province(No.2016KZD-XM031);Science and Technology Project of Guangzhou City(No.201707010467)

摘　　要：Four new 3,4-seco-labdane diterpenoids,nudiflopenes J-M,were isolated from the leaves of Callicarpa nudiflora along with six known compounds.The structures of these diterpenoids were determined by comprehensive spectroscopic analysis.All the isolated compounds were evaluated for their inhibitory effects on NO production in LPS-stimulated RPMs and RAW264.7 cells.The results suggest that nudiflopenes J-M and other four known compounds showed significant inhibitory effects against NO production comparable to the positive control dexamethasone.Four new 3, 4-seco-labdane diterpenoids, nudiflopenes J-M, were isolated from the leaves of Callicarpa nudiflora along with six known compounds. The structures of these diterpenoids were determined by comprehensive spectroscopic analysis. All the isolated compounds were evaluated for their inhibitory effects on NO production in LPS-stimulated RPMs and RAW264.7 cells. The results suggest that nudiflopenes J-M and other four known compounds showed significant inhibitory effects against NO production comparable to the positive control dexamethasone.

关 键 词：CALLICARPA nudiflora VERBENACEAE 3 4-seco-Labdane DITERPENOID ANTI-INFLAMMATORY RPMs RAW264.7 

分 类 号：R284[医药卫生—中药学] R965[医药卫生—中医学]