DITERPENOID

作品数：163被引量：350H指数：9
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Ent-pimarane and ent-kaurane diterpenoids from Siegesbeckia pubescens and their anti-endothelial damage effect in diabetic retinopathy
《Chinese Journal of Natural Medicines》2025年第2期234-244,共11页Mengjia Liu Tingting Luo Rongxian Li Wenying Yin Fengying Yang Di Ge Na Liu 
supported by the National Natural Science Foundation of China (No.82073728);the Natural Science Foundation of Shandong Province (No.ZR2021MH357)。
Diabetic retinopathy,a prevalent and vision-threatening microvascular complication of diabetes mellitus,is the leading cause of blindness among middle-aged and elderly individuals.Natural diterpenoids isolated from Si...
关键词：Siegesbeckia pubescens Natural diterpenoid Diabetic retinopathy Oxidative stress Inflammatory response 
The diterpenoid esters from Euphorbia lathyris L. induce intestinal inflammation via LXRα/ABCA1-regulated lipid rafts and TLR4-mediated pathway
《Natural Therapy Advances》2024年第4期30-37,共8页Hui-Nan Wang Xiao-Yu Wang Pei-Hua Wang Ming-Rui Jiang Si-Yuan Ma Hai-Ting Zhu Jun-Li Zhang Xin-Ning Zhang Wen-Jing Chen Yi-Fan Mao Hua Xu Ying-Zi Wang 
supported by the National Natural Science Foundation of China(Grant no.82074021,82374040);the Beijing Nova Program(Grant no.20240484548).
Background:Diterpenoid esters are considered to be the main toxic components and bioactive constituents of Euphorbia lathyris L.(EL).Euphorbia factors L1(EF1),L2(EF2),and L3(EF3),the main diterpenoid esters of EL,have...
关键词：diterpenoid esters Euphorbia lathyris L. LXRα/ABCA1 lipid rafts TLR4 
Diterpenoids from Mangrove Plant Excoecaria agallocha L.and Their Anti-neuroinflammatory Activities
《有机化学》2024年第11期3526-3530,共5页Junyi Li Lu Yang Mingbin Chen Yong Rao Zhongping Jiang Ling Huang 
国家自然科学基金(Nos.82204275,8216065);海南省自然科学基金(No.323MS014)资助项目。
Normal-phase and reversed-phase silica gel column chromatography and semi-preparative high performance liquid chromatography were applied to study the chemical constituents of the stems and twigs of the Hainan mangrov...
关键词：Excoecaria agallocha L. mangrove plant kaurane diterpenoid labdane diterpenoid anti-neuroimflamation 
Hordedane diterpenoid phytoalexins restrict Fusarium graminearum infection but enhance Bipolaris sorokiniana colonization of barley roots
《Molecular Plant》2024年第8期1307-1327,共21页Yaming Liu Dario Esposto Lisa K.Mahdi Andrea Porzel Pauline Stark Hidayat Hussain Anja Scherr-Henning Simon Isfort Ulschan.Bathe Ivan F.Acosta Alga Zuccaro Gerd U.Balcke Alain Tissier 
TI 800/7-1 and TI 800/7-2(SPP 2125 DECRyPT)from the Deutsche Forschungsgemeinschaft,Germany,to A.T.We also acknowledge support from the Cluster of Excellence on Plant Sciences(CEPLAS);the Deutsche Forschungsgemeinschaft under Germany's ExcellenceStrategy-EXC 2048/1-Project ID:390686111and the grant ZU263/11-2(SPP 2125DECRyPT)to A.Z.
Plant immunity is a multilayered process that includes recognition of patterns or effectors from pathogens to elicit defense responses.These include the induction of a cocktail of defense metabolites that typically re...
关键词：BARLEY Hordeum vulgare diterpenoid phytoalexins gene cluster pathogenic fungi Bipolaris sorokininiana Fusarium graminearum 
Discovery of a highly potent and orally available importin-β1 inhibitor that overcomes enzalutamide-resistance in advanced prostate cancer
《Acta Pharmaceutica Sinica B》2023年第12期4934-4944,共11页Jia-Luo Huang Xue-Long Yan Dong Huang Lu Gan Huahua Gao Run-Zhu Fan Shen Li Fang-Yu Yuan Xinying Zhu Gui-Hua Tang Hong-Wu Chen Junjian Wang Sheng Yin 
supported by the Natural Science Foundation of China(Nos.82273804,81973195,81872891,and 81973203);the Southerm Marine Science and Engineering Guangdong Laboratory(Zhuhai)(No.SML2021SP301,China);Open Program of Shenzhen Bay Laboratory(No.SZBL2021080601007,China);the Guangdong Natural Science Funds for Distinguished Young Scholar(No.2019B151502016,China);Guangdong-Hong Kong-Macao research team project of the Guangdong Basic and Applied Basic Research Foundation(No.2022B1515130008,China).
Nuclear transporter importin-β1 is emerging as an attractive target by virtue of its prevalence in many cancers.However,the lack of druggable inhibitors restricts its therapeutic proof of concept.In the present work,...
关键词：Importin-β1 CRPC Drug discovery Enzalutamide-resistance Natural product Cancer Daphnane diterpenoid Nuclear transporter 
Engineering Nannochloropsis oceanica for the production of diterpenoid compounds
《mLife》2023年第4期428-437,共10页Zhi-Yan Du Wajid W.Bhat Eric Poliner Sean Johnson Conor Bertucci Eva Farre Bjoern Hamberger 
U.S.Department of Agriculture National Institute of Food and Agriculture (HATCH project HAW05047-H and 2023-70003-38783);Center for Tropical and Subtropical Aquaculture (Grant No.2020-38500-32559);the National Science Foundation (Grant Number 2121410);the US Department of Energy-Great Lakes Bioenergy Research Center Cooperative Agreement DE-SC0018409,start-up funding from the Department of Molecular Biology and Biochemistry;support by the USDA National Institute of Food and Agriculture,HATCH project MICL02454.B.H;supported by the National Science Foundation (Grant Number 1737898);E.M.F acknowledges funding from the National Science Foundation (IOS-134721).
Photosynthetic microalgae like Nannochloropsis hold enormous potential as sustainable,light-driven biofactories for the production of high-value natural products such as terpenoids.Nannochloropsis oceanica is distingu...
关键词：casbene MICROALGAE plastid targeting synthetic biology terpene synthase 
Multi-omics analysis reveals the evolutionary origin of diterpenoid alkaloid biosynthesis pathways in Aconitum被引量：3
《Journal of Integrative Plant Biology》2023年第10期2320-2335,共16页Dake Zhao Ya Zhang Huanxing Ren Yana Shi Ding Dong Zonghang Li Guanghong Cui Yong Shen Zongmin Mou Edward JKennelly Luqi Huang Jue Ruan Suiyun Chen Diqiu Yu Yupeng Cun 
supported by funding from the CAS “Pioneer Hundred Talents” Program and Strategic Priority Research Program of the Chinese Academy of Sciences (XDB31000000) to Y.C.;National Natural Science Foundation of China (Nos. 31960082, 32270395, and 31960096);Yunnan Fundamental Research Projects (No. 202101AS070021) to D.Z。
Diterpenoid alkaloids(DAs) have been often utilized in clinical practice due to their analgesic and anti-infammatory properties. Natural DAs are prevalent in the family Ranunculaceae, notably in the Aconitum genus. Ne...
关键词：Aconitum vilmorinianum acute toxicity biosynthetic pathway diterpenoid alkaloid evolutionary origin genome assembly 
Flavidanolides A and B from Isodon flavidus
《Chinese Chemical Letters》2023年第9期160-164,共5页Jiang-Hai Ye Guo-Yong Luo Chen-Liang Zhao Zheng-Ming Liang Jin-Huai Wei Ya-Hua Liu Kang He Lu-Tai Pan Jing-Jie Zhang Juan Zou Hong-Jie Zhang 
supported by the National Natural Science Foundation of China(No.82204605);the National Natural Science Foundation of China(No.81560709);the Technology Fund of Guizhou Administration of Traditional Chinese Medicine(No.QZYY-2022019);Science and Technology Tip-top Talent Foundation of Universities in Guizhou Province(No.Qian jiao he KY(2021)034);the Research Grant Council of the Hong Kong Special Administrative Region,China(No.HKBU 12102219);the University Grants Committee of the Hong Kong Special Administrative Region,China(UGC Research Matching Grant Scheme,No.RMG2019_1_19)。
A phytochemical investigation on Isodon flavidus led to the isolation of flavidanolide A(1),a rearranged diterpenoid featuring a six/seven/five-membered tricyclic skeleton,together with flavidanolide B(2),an uncommon ...
关键词：Isodon flavidus Rearranged six/seven/five-membered SKELETON Heterodimeric diterpenoid Plausible biosynthetic pathway Antiinflammatory effects 
Improving cancer immunotherapy via co-delivering checkpoint blockade and thrombospondin-1 downregulator被引量：4
《Acta Pharmaceutica Sinica B》2023年第8期3503-3517,共15页Qingqing Xiao Xiaotong Li Chang Liu Yuxin Jiang Yonglong He Wanting Zhang Helena SAzevedo Wei Wu Yuanzheng Xia Wei He 
supported by the National Natural Science Foundation of China(Nos.81872823,82073782 and 81973524);the Double First-Class(CPU2018PZQ13,China)of the CPU;the Shanghai Science and Technology Committee(19430741500,China);the Key Laboratory of Modern Chinese Medicine Preparation of Ministry of Education of Jiangxi University of Traditional Chinese Medicine(zdsys-202103);the Project Program of State Key Laboratory of Natural Medicines,China Pharmaceutical University(No.SKLNMZZ202004);Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University),Ministry of Education(GKEKF202010);。
The use of checkpoint-blockade antibodies is still restricted in several malignancies due to the modest efficacy,despite considerable success in anti-tumor immunotherapy.The poor response of cancer cells to immune des...
关键词：IMMUNOTHERAPY Diterpenoid-based conjugate Checkpoint blockade Thrombospondin-1 CO-DELIVERY Liposomes 
New di-spirocyclic labdane diterpenoids from the aerial parts of Leonurus japonicus
《Chinese Journal of Natural Medicines》2023年第7期551-560,共10页CAO Xinxin WANG Xinxin ZHANG Yu XU Defeng SONG Xiuqing YU Jinhai BAO Jie ZHANG Junsheng ZHANG Hua 
supported by the Natural Science Foundation of Shandong Province(No.JQ201721);the Young Taishan Scholars Program(No.tsqn20161037).
Phytochemical investigation on the ethanol extract of a well-known medicinal herb Leonurus japonicus,led to the separation of 18 labdane type diterpenoids(1-18).Through comprehensive spectroscopic analyses and quantum...
关键词：Leonurus japonicus LABDANE DITERPENOID Neuroprotective activity 
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