New di-spirocyclic labdane diterpenoids from the aerial parts of Leonurus japonicus  

作　　者：CAO Xinxin WANG Xinxin ZHANG Yu XU Defeng SONG Xiuqing YU Jinhai BAO Jie ZHANG Junsheng ZHANG Hua 

机构地区：[1]School of Biological Science and Technology,University of Jinan,Jinan 250022,China

出　　处：《Chinese Journal of Natural Medicines》2023年第7期551-560,共10页中国天然药物（英文版）

基　　金：supported by the Natural Science Foundation of Shandong Province(No.JQ201721);the Young Taishan Scholars Program(No.tsqn20161037).

摘　　要：Phytochemical investigation on the ethanol extract of a well-known medicinal herb Leonurus japonicus,led to the separation of 18 labdane type diterpenoids(1-18).Through comprehensive spectroscopic analyses and quantum chemical calculations,these compounds were structurally characterized as six new interesting 5,5,5-di-spirocyclic ones(1-6),two new(7 and 8)and six known(13-18)interesting 6,5,5-di-spirocyclic ones,a new rare 14,15-dinor derivative(9),and three new ones incorporating a y-lactone unit(10-12).An in vitro neuroprotective assay in RSC96 cells revealed that compounds 7 and 12 exhibited neuroprotective activity in a concentration-dependent way,comparable to the reference drug N-acetylcysteine.

关 键 词：Leonurus japonicus LABDANE DITERPENOID Neuroprotective activity 

分 类 号：R284[医药卫生—中药学]