食管癌根治术后三维放疗患者预后的影响因素分析  

Prognostic factors of postoperative radiotherapy with three dimensional conformal technology for patients with esophageal cancer

作　　者：周俊东[1] 宁忠华[2] 邹士涛[1] 吴锦昌[1] ZHOU Jundong;NING Zhonghua;ZOU Shitao;WU Jinchang(Department of Radio-Oncology,Nanjing Medical University Affiliated Suzhou Hosipital,Suzhou 215001,China;Department of Radio-oncology,First People s Hospital of Changzhou,Changzhou 213000,China)

机构地区：[1]南京医科大学附属苏州医院放疗科,江苏苏州215001 [2]常州市第一人民医院放疗科,江苏常州213000

出　　处：《中国肿瘤外科杂志》2019年第4期251-254,共4页Chinese Journal of Surgical Oncology

基　　金：江苏省333人才项目(BRA2016071);江苏省六大人才高峰项目(WSN-095)

摘　　要：目的 探讨食管癌根治术后行三维放疗患者生存的影响因素。方法回顾分析2005年1月至2009年12月常州市第一人民医院收治的食管癌根治术后行三维放疗的114例患者的临床资料。采用Kaplan-Meier生存分析法和log-rank统计检验各临床病理特征与食管癌根治术后辅助放疗患者预后的相关性。结果114例患者术后放疗后3、5年总体生存率分别为57%和42%;Kaplan-Meier生存分析法和log-rank统计检验方法分析显示淋巴结转移阳性、淋巴结转移区域数目较多、TNM分期越高、脉管癌栓阳性和Ki-67高表达的食管癌根治术后放疗患者的预后较差,反之则患者预后较好。结论淋巴结转移、淋巴结转移区域数目、TNM分期、脉管癌栓和Ki-67表达是食管癌术后放疗患者生存的影响因素。Objective to investigate the prognostic factors of patients with esophageal cancer who underwent radical esophagectomy with postoperative radiotherapy using three dimensional conformal technology.Methods One hundred and fourteen cases with esophageal cancer who underwent radical esophagectomy with postoperative radiotherapy were selected from the First Hospital of Changzhou during2005 to2009.The correlation between clinicopathological features and prognosis of postoperative radiotherapy were evaluated using Kaplan-Meier method and log-rank test.Results The3- and 5-year overall survival rates of 114 cases were 57% and 42% respectively.Kaplan-Meier method and log-rank test demonstrated that positive lymph node metastasis,increased number of regional lymph node metastasis,advanced TNM stage,blood and lymphatic vessel invasion,and high expression of Ki-67 were associated with poor prognosis of esophageal cancer patients with post-operative radiotherapy.Conversely,patients had a good prognosis.Conclusions The prognostic factors of esophageal cancer patients with postoperative radiation include lymph node metastasis,the number of regional lymph node metastasis,TNM stage,lymphovascular invasion, and Ki-67 expression.

关 键 词：食管癌 术后放疗 三维放疗 预后因素 KI-67 

分 类 号：R735.1[医药卫生—肿瘤]