基于纳米材料的刺激响应策略在肿瘤治疗中的研究进展  

Progress of Stimulation Response Strategy Based on Nanomaterials in Tumor Therapy

作　　者：程凯[1] 周洁[1] 陈钰[1] 陈道桢[1] CHENG Kai;ZHOU Jie;CHEN Yu;CHEN Daozhen(Department of Laboratory,Wuxi Hospital for Maternal and Child Health Care Affiliated to Nanjing Medical University,Wuxi 214002,China)

机构地区：[1]南京医科大学附属无锡市妇幼保健院检验科

出　　处：《肿瘤防治研究》2019年第9期841-846,共6页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金(81372480);江苏省自然科学基金(BK20171148);江苏省卫计委面上科研课题(H2018114)

摘　　要：化疗作为肿瘤主要的治疗方法具有靶向性差、不良反应严重等缺点。随着纳米医学的不断发展,研究发现基于纳米材料的刺激响应策略可以通过肿瘤微环境的pH、氧化还原、ROS和酶等响应条件以及外部的光、磁等响应条件促进化疗药物在肿瘤内的聚集、摄取和释放,从而提高药物的安全性和杀伤效果。本文综述了常见的基于纳米材料的刺激响应策略及其在肿瘤治疗中的作用,为其在临床应用以及未来的研究发展提供一定参考。Most of the conventional chemotherapeutic agents against cancer have poor targeting and efficacy. With the development of nanomedicine, it is found that the stimulating response strategy based on nanomaterials can promote the gather, ingest and release of chemotherapeutic drugs in tumors through the response conditions of pH, redox, ROS and enzymes of the tumor microenvironment and external light, magnetic and other response conditions, thereby improving the safety and killing effect of the drug. This paper reviews the common nanomaterial-based stimulation response strategies and their role in tumor therapy, to provide some references for clinical application and future research.

关 键 词：纳米医学 刺激响应 肿瘤治疗 

分 类 号：R730.5[医药卫生—肿瘤]