lncRNA靶向miRNA调控Wnt信号通路在结直肠癌中的研究进展  

Advances in the study of lncRNA targeting miRNAs regulating Wnt signaling pathway in colorectal cancer

作　　者：孙灯众 刘牧林[1] 吴华彰[2] 史维俊 SUN Dengzhong;LIU Mulin;WU Huazhang;SHI Weijun(Department of Gastrointestinal Surgery,The First Affiliated Hospital of Bengbu Medical College,Bengbu 233003,China;Department of Biological Sciences,Bengbu Medical College)

机构地区：[1]蚌埠医学院第一附属医院胃肠外科,安徽蚌埠233003 [2]蚌埠医学院生物科学系

出　　处：《沈阳医学院学报》2019年第5期456-460,共5页Journal of Shenyang Medical College

基　　金：国家自然科学基金(No.21707002);安徽省高校自然科学研究项目(No.KJ2017A213,No.KJ2017A219,No.gxyq2018035);研究生创新计划(No.Byycx1825)

摘　　要：长链非编码RNA(long non-coding RNA,lncRNA)是一类长度大于200nt的非编码RNA,而微小RNA(miRNA)是一类长度约为22nt的内生小RNA;越来越多的研究证据表明,lncRNA通过靶向miRNA调控Wnt信号通路并在肿瘤的发生发展中发挥重要作用。结直肠癌是外科常见的恶性肿瘤,诊断及预后均不理想。随着研究的进一步深入,lncRNA、miRNA以及Wnt信号通路在结直肠癌发生发展中的调控机制逐渐明确。本文将对lncRNA靶向miRNA调控Wnt信号通路在结直肠癌中的研究进展进行综述。Long non-coding RNA (lncRNA) is a type of non-coding RNA that exceed 200 nucleotides (nt) in length. MicroRNA (miRNA) is a type of endogenous, small non-coding RNA with the length about 22 nt. Numerous studies have shown that lncRNA regulates Wnt signaling pathway by targeting miRNA and plays an important role in tumor development and progression. Colorectal cancer (CRC) is a common malignant tumor of the gastrointestinal tract. The diagnosis of CRC is difficult and the prognosis is poor. Several studies have shown that the regulation mechanism of lncRNA, miRNA and Wnt signaling pathway is involved in the development of CRC. This article reviews the roles of lncRNA in the progression of CRC by targeting miRNA and enhancing Wnt signaling pathway.

关 键 词：长链非编码RNA 微小RNA WNT信号通路 结直肠癌 

分 类 号：R735.3[医药卫生—肿瘤]