成人出血型烟雾病联合脑血运重建效果分析  

Surgical treatment of revascularization for adult patients with hemorrhagic moyamoya disease

作　　者：马继伟[1] 赵新利[1] 赵树鹏[1] 黄立勇[1] 周文科[1] 张新中[1] Ma Jiwei;Zhao Xinli;Zhao Shupeng;Huang Liyong;Zhou Wenke;Zhang Xinzhong(Department of Neurosurery,The First Affliated Hospital of XinXiang Medical University Henan Xinxiang 453100,China)

机构地区：[1]新乡医学院第一附属医院神经外科

出　　处：《河南外科学杂志》2019年第5期1-3,共3页Henan Journal of Surgery

基　　金：国家自然科学基金p38/DJ-1介导蛛网膜下腔出血早期脑损伤后mitophagy的分子机制研究(项目批准号:81541030)

摘　　要：目的分析成人出血型烟雾病联合脑血运重建的效果。方法对27例成人出血型烟雾病患者,应用颅内外联合脑血运重建技术治疗,比较术前与术后6个月患者脑动脉血管造影(DSA)、脑CT灌注(CTP)图像,改良Rankin量表(mRS)评分,评价及随访治疗效果。结果27例均手术成功,无手术死亡病例;术后6个月血管吻合口通畅率为70.37%(19/27),脑皮层侧支血管形成增多;脑组织灌注、生活质量(mRS评分)较术前明显改善(P<0.05);随访期间无再出血或缺血等脑血管事件发生。结论联合脑血运重建手术治疗出血型烟雾病,能增加脑组织灌注,改善患者的临床症状和生活质量,安全有效。Objective To explore and evaluate the clinical efficacy of combined cerebral revascularization in adult patients with hemorrhagic moyamoya disease.Methods twenty-seven patients with hemorrhagic moyamoya disease were treated with extracranial and intracranial combined cerebral revascularization.DSA,brain CTPand mRS score were compared before and 6 months after surgery to evaluate the effect of surgical treatment.Results twenty-seven cases were successfully operated without death.The patency rate of vascular anastomosis was 70.37%(19/27),and collateral vessel formation was increased.Cerebral hemodynamic parameters and mRS scores were significantly improved(P<0.05).Conclusion Combined cerebral revascularization is safe and effective,which can increase cerebral perfusion,and improve the symptoms and the quality of life for patients with hemorrhagic moyamoya disease.

关 键 词：颞浅动脉 出血型烟雾病 脑室出血 脑血运重建 

分 类 号：R743[医药卫生—神经病学与精神病学]