广西永福地区长寿老人代谢状况与认知障碍的关联研究  

Correlation between metabolic status and cognitive impairment of longevous population in Guangxi Yongfu region

作　　者：付棉[1] 吕渊[1] 梁梅[1] 李海洪[1] 何香花[1] 黄金山[1] 张为[1] 甘文玉[1] 庞国防[1] 胡才友[1] FU Mian;LYU Yuan;LIANG Mei;LI Haihong;HE Xianghua;HUANG Jinshan;ZHANG Wei;GAN Wenyu;PANG Guofang;HU Caiyou(Department of Neurology,Jiangbin Hospital,Nanning,Guangxi 530021,China)

机构地区：[1]广西壮族自治区江滨医院

出　　处：《重庆医学》2019年第18期3087-3090,共4页Chongqing medicine

基　　金：国家自然科学基金地区科学基金项目(31760299,81460203);广西自然科学基金重点项目(2014GXNSFDA118028);广西自然科学基金项目(桂科自0991198,2018GXNSFAA138156);广西医疗卫生适宜技术研究与开发项目(S201402-1);广西壮族自治区卫生和计划生育委员会自筹经费科研课题(Z20180847,Z20170162)

摘　　要：目的探索永福地区长寿老年人代谢综合征(MetS)及其各组分与认知障碍的关系。方法调查广西永福地区长寿老年人(≥90岁)239例,检测身体代谢指标及评估认知功能,了解该地区长寿老年人MetS的患病情况,分析MetS及其各组分与认知障碍的关联。结果该地区长寿老年人MetS的患病率为14.6%,女性(18.0%)高于男性(3.6%),差异有统计学意义(χ^2=7.174,P=0.007)。未发现MetS作为整体与认知障碍相关,通过各组分与认知障碍的关联分析,发现低HDL-C血症是长寿老人认知障碍的危险因素(χ^2=5.326,P=0.021)。通过多因素Logistic回归分析发现高LDL-C血症是该地区长寿老年人群认知功能的保护因素(OR=0.337,95%CI:0.136~0.833)。结论广西永福地区长寿老年人MetS具有较低的患病率,而血脂代谢异常与认知障碍有关。Objective To investigate the correlation between Metabolic syndrome (MetS) and its components,and the cognitive impairment of longevous population in Yongfu region. Methods A total of 239 longevous people in Yongfu region were investigated.Their metabolism indexes were measured,and their cognitive function was evaluated.The prevalence of MetS among local longevous population in Yongfu region was studied,and the correlation between MetS and its components,and the cognitive impairment was also analyzed. Results The prevalence of MetS among longevous population in this region was 14.6% in which women (18.0%) was higher than men (3.6%).The difference was statistically significant (χ^2=7.174, P = 0.007 ).MetS as a whole was not found associated with the cognitive impairment,but low high-density lipoprotein cholesterol (HDL-C) is a risk factor for the cognitive impairment through the correlation analysis of MetS components and the cognitive impairment (χ^2=5.326, P=0.021).High LDL-C was found to be a protective factor for the cognitive function among longevous population in this area through multiple Logistic regression analysis (OR =0.337,95% CI :0.136-0.833). Conclusion The longevous population in Guangxi Yongfu region have a low prevalence of MetS while dyslipidemia may be associated with the cognitive impairment.

关 键 词：长寿 代谢综合征 脂类代谢 认知障碍 组分 

分 类 号：R749.25[医药卫生—神经病学与精神病学]