氟西汀联合重复经颅磁刺激低频刺激辅助运动区治疗强迫障碍的研究  

Study of Fluoxetine Combined with Low-frequency Repetitive Transcranial Magnetic Stimulation of Supplementary Motor Area in the Treatment of Obsessive Compulsive Disorder

作　　者：余寒[1] 龙珊珊[1] 蒋硕[1] 周勇[1] Yu Han;Long Shanshan;Jiang Shuo(Zigong Mental Health Center,Zigong,Sichuan 643020,China)

机构地区：[1]自贡市精神卫生中心

出　　处：《四川医学》2019年第8期811-814,共4页Sichuan Medical Journal

摘　　要：目的探讨重复经颅磁刺激(rTMS)低频刺激辅助运动区治疗强迫障碍的疗效。方法选择58例强迫障碍患者,随机分为药物治疗组(n=29例)、药物联合rTMS组(n=29例),于治疗前、治疗后第2、4、6、8周末行Y-BOCS评定临床疗效,TESS评定不良反应。结果药物治疗组Y-BOCS评分在治疗的第6周、第8周末较治疗前有明显降低,差异有统计学意义(P<0.05);rTMS治疗组Y-BOCS评分在治疗的第4周末较治疗前有明显降低,差异有统计学意义(P<0.05);rTMS治疗组Y-BOCS评分在治疗的第4周、第6周、第8周与药物治疗组比明显下降,差异有统计学意义(P<0.05)。结论氟西汀联合重复经颅磁刺激(rTMS)治疗强迫障碍起效快,不良反应少,安全性高。Objective To investigate the efficacy of repetitive transcranial magnetic stimulation( rTMS) with low frequency stimulation of supplementary motor area in the treatment of obsessive-compulsive disorder.Methods A total of 58 patients with obsessive- compulsive disorder were randomly divided into the drug treatment group( n = 29 cases) and the drug combined with rTMS group( n = 29 cases).Y-BOCS was used to assess clinical outcomes and TESS to assess adverse events before treatment,the 2nd, 4th,6th and 8th weekend after treatment.Results The Y-BOCS score of the drug treatment group at the 6th and 8th weekend after treatment was significantly lower than that before treatment( P<0.05).The Y-BOCS score of the rTMS treatment group at the 4th weekend of treatment was significantly lower than that before treatment( P<0.05);The Y-BOCS score of the rTMS treatment group was significantly lower than that of the drug treatment group at the 4th,6th and 8th weekend of treatment( P<0.05).Conclusion Fluoxetine combined with repetitive transcranial magnetic stimulation( rTMS) is effective in the treatment of obsessive-compulsive disorder,which has less adverse reactions and high safety.

关 键 词：强迫障碍 重复经颅磁刺激 辅助运动区 

分 类 号：R749[医药卫生—神经病学与精神病学]