深部脑刺激的临床应用进展  

Recent advance in clinical application of deep brain stimulation

作　　者：泮旭峰 余国峰[2] Pan Xufeng;Yu Guofeng(Graduate School of Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China;Department of Neurosurgery, People's Hospital of Quzhou, Quzhou 324000, China)

机构地区：[1]浙江中医药大学研究生院,杭州310053 [2]衢州市人民医院神经外科,324000

出　　处：《中华神经医学杂志》2019年第9期957-961,共5页Chinese Journal of Neuromedicine

摘　　要：目前,深部脑刺激(DBS)被广泛应用于多种神经精神疾病的治疗,在癫痫、帕金森病(PD)、特发性震颤、药物难治性精神性疾病、药物难治性疼痛、改善觉醒及认知功能、成瘾性疾病等中枢神经性疾病的治疗过程中展现出独特的优势。经过30多年的临床研究、动物实验及材料研究,DBS的使用范围及模式得到了充分发展,在寻求更佳的刺激靶点及刺激模式方面取得重要进展。疾病的复杂性及个体性导致每位患者对DBS治疗的反应存在差异,因此需要进一步明确其作用机制、寻找更佳治疗靶点及参数来适应更高的临床要求。本文现围绕DBS的临床应用进展综述如下。Deep brain stimulation is widely used for treatment of neuropsychiatric diseases, showing its unique advantages in the treatment of central nervous diseases, such as epilepsy, Parkinson's disease, essential tremor, drug-refractory psychiatric diseases, drug-refractory pain, improvement of arousal and cognitive functions, and addiction diseases. After more than 30 years of clinical research, animal experiments and material research, the scopes and modes of DBS use have been fully developed, and important progress has been made in seeking better stimulation targets and modes. The complexity and individuality of the disease lead to differences in the response of each patient to DBS treatment, so it is necessary to further clarify its mechanism of action and explore better therapeutic targets and parameters to meet higher clinical requirements. This paper reviews the clinical application of DBS as follows.

关 键 词：深部脑刺激 神经系统疾病 精神疾病 意识障碍 疼痛 

分 类 号：R74[医药卫生—神经病学与精神病学]