用于治疗乳腺癌新型酞菁光敏剂的实验研究  

Experimental Studies on a New Phthalocyanine Photosensitizer for Breast Cancer

作　　者：戴涛 胡萍[2,3] 杨永帅 刘见永 潘小宏 陈卓 DAI Tao;HU Ping;YANG Yong-shuai;LIU Jian-yong;PAN Xiao-hong;CHEN Zhuo(College of Life Sciences,Fujian Agriculture and Forestry University,Fuzhou 350002,China;State Key Laboratory of Structural Chemistry,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou350002,China;College of Chemistry, Fuzhou University, Fuzhou 35QU6,China)

机构地区：[1]福建农林大学生命科学学院,福建福州350002 [2]中国科学院福建物质结构研究所结构化学国家重点实验室,福建福州350002 [3]福州大学化学学院,福建福州350116

出　　处：《福建师范大学学报（自然科学版）》2019年第5期67-73,共7页Journal of Fujian Normal University：Natural Science Edition

基　　金：国家自然科学基金面上项目(81572944、21471033);福建省引进高层次创业创新人才项目(闽委人才[2018]8-1);福建省自然科学基金资助项目(2015J01419、2018J05031)

摘　　要：合成并观察带正电荷的酞菁光敏剂(ZnPc(α-MPz)2)的体内外抗乳腺癌光动力作用疗效.体外细胞实验结果表明,该光敏剂对人源乳腺癌细胞(MCF-7)具有良好的抗肿瘤活性,而对正常的人胚肺成纤维细胞(HELF)没有明显影响.在体内的动物实验结果也证实,该光敏剂比对照药(ZnPc-OH)具有更强的抗肿瘤作用以及肿瘤成像.相关组织切片结果也显示:光敏剂ZnPc(α-MPz)2对小鼠肿瘤组织有明显破坏作用.综合上述实验结果,提示光敏剂ZnPc(α-MPz)2在肿瘤部位蓄积,增强其肿瘤成像并发挥其靶向抗肿瘤作用.We investigated the anti-breast cancer effects of phthalocyanine(ZnPc(α-MPz)2) both in vivo and in vitro.ZnPc(α-MPz)2 showed excellent antitumor activity against human breast cancer cells(MCF-7) with no toxicity to human embryonic lung fibroblasts(HELF) in vitro.Comparing with ZnPc-OH,ZnPc(α-MPz)2 present its high-efficient anti-tumor effects in tumor-bearing mice along with good-quality tumor imaging.Histopathological examinations on these mice further confirmed that obvious change was observed in tumors of mice after they received ZnPc(α-MPz)2.These results indicated that ZnPc(α-MPz)2 is more likely to accumulate in tumor sites which probably due to its positive charges and thus play the anti-tumor effects more efficiently.

关 键 词：酞菁 光敏剂 乳腺癌 肿瘤成像 组织病理切片 

分 类 号：R73-3[医药卫生—肿瘤]