植入式柔性神经电极在活体脑电信号检测中的研究进展  

Implantable and Flexible Electronics for in Vivo Brain Activity Recordings

作　　者：王晋芬[1,2,5] 田慧慧 方英[1,2,3,4] WANG Jin-Fen;TIAN Hui-Hui;FANG Ying(CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology,Beijing 100190,China;CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,National Center for Nanoscience and Technology,Beijing 100190,China;University of Chinese Academy of Sciences,Beijing 100049,China;CAS Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China;State Key Laboratories of Transducer Technology,Chinese Academy of Sciences,Beijing 100190,China)

机构地区：[1]中国科学院纳米科学卓越创新中心,国家纳米科学中心,北京100190 [2]中国科学院纳米生物效应与安全性重点实验室,国家纳米科学中心,北京100190 [3]中国科学院大学,北京100049 [4]中国科学院脑科学与智能技术卓越创新中心,上海200031 [5]传感技术联合国家重点实验室,中国科学院,北京100190

出　　处：《分析化学》2019年第10期1549-1558,共10页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(Nos.21790393,61971150);中国科学院先导B项目(No.XDB32030100)资助~~

摘　　要：植入式神经电极是记录神经电生理信号的一种重要工具,具有单细胞的空间分辨率和亚毫秒级的时间分辨率,在神经科学和神经修复领域具有重要的应用。微纳米加工技术的发展,为植入式神经电极的构建提供了更多的解决方案。基于微纳米加工的植入式刚性电极,由于存在与大脑组织的力学性能不匹配的问题,容易造成大脑组织的免疫反应,影响神经电信号的长期稳定测量。而近年出现的新型植入式柔性神经电极,可与脑组织形成兼容性的界面,引起的免疫反应小,有利于神经电信号的长期稳定测量。此外,植入式柔性神经电极的微型化、高密度和多功能集成也是脑研究新技术的研究热点。本文主要对近年用于活体脑电信号检测的植入式柔性神经电极的相关研究进展进行了评述,包括柔性神经电极结构、电极组织界面、植入方法、微型化方法和集成方法等。Implantable electronics are essential for electrophysiological recording at single-neuron and sub-millisecond resolution in the fields of neuroscience and neuroprosthesis.Advances in nano/microfabrication techniques offer new and exciting opportunities for the development of high-density implantable electronics.However,the mechanical mismatch between microfabricated rigid electronics and soft brain tissues has been shown to cause inflammatory responses,leading to signal degradation during chronic recording.Recently,flexible electronics with improved mechanical compatibility to brain tissues have been intensively investigated to improve the performance of chronic neural recordings.Flexible electronics can form conformal interfaces with brain tissue,resulting in minimized inflammatory responses and stable signal recordings.In addition,ultra-small,high-density,and multiple-functionality are also desirable features of flexible neural electronics.In this review,we highlight recent progress in microfabricated flexible electronics for in vivo brain activity recordings,with a focus on structural design,brain/tissue interface,implantation method,minimization and multifunctional integration.

关 键 词：柔性神经电极 植入式神经电极 免疫反应 电生理记录 活体 评述 

分 类 号：R741.044[医药卫生—神经病学与精神病学] O646.54[医药卫生—临床医学]