长链非编码RNA在自噬相关基因表达调控中的研究进展  

Advances in the regulation of autophagy related genes by lncRNA

作　　者：周娟 龙云铸[1] ZHOU Juan;LONG Yunzhu(Department of Infectious Diseases, Affiliated Zhuzhou Hospital,Xiangya School of Medicine,Central South University,Zhuzhou Hunan 412007, China)

机构地区：[1]中南大学湘雅医学院附属株洲医院感染内科

出　　处：《临床与病理杂志》2019年第9期2052-2056,共5页Journal of Clinical and Pathological Research

摘　　要：现有研究已充分证实细胞自噬与人体诸多疾病的发生和转归密切相关,靶向调控自噬已经成为临床疾病诊疗领域新的突破点。在自噬的起始与调控中,涉及复杂的基因转录控制网络与翻译后的修饰,而长链非编码RNA(long noncoding RNA,lncRNA)是参与基因表达调控的关键分子,在转录及转录后等多层次调控蛋白质的表达,因此越来越多的研究开始关注自噬调控相关的lncRNA在疾病发生发展中的角色。Abundant researches have confirmed that autophagy show an intimate association with the occurrence and progression of many diseases in human, consequently consider that targeting at the regulation of autophagy has become a new avenue to the diagnosis and treatment of related diseases. Long chain noncoding RNA (lncRNA) have a critical role to regulation of the fairly complex gene transcription and translated network, which are equally involved in multi-level initiation and regulation of autophagy that have been proved recently. Therefore, increasing studies support that lncRNA manipulate autophagy largely by means of regulation of protein expression level to involve in the development of the disease.

关 键 词：非编码RNA 自噬 自噬相关基因 基因表达调控 

分 类 号：R363[医药卫生—病理学]