奥曲肽联合鼻空肠置管肠内低脂营养预防白血病患儿门冬酰胺酶相关性胰腺炎的治疗体会  

Experiences in using octreotide combined with nasojejunal catheterization and enteral low-fat nutrition to prevent asparaginase-associated pancreatitis in leukemia children

作　　者：张作慧 武双双[1] 马翠[1] 李春怀[1] 王玥[1] ZHANG Zuohui;WU Shuangshuang;MA Cui;LI Chunhuai;WANG Yue(Department of Pediatric Hematology, The First Hospital of Jilin University,Changchun 130021)

机构地区：[1]吉林大学第一医院小儿血液科

出　　处：《中国小儿血液与肿瘤杂志》2019年第4期203-206,共4页Journal of China Pediatric Blood and Cancer

摘　　要：目的回顾性总结应用奥曲肽联合鼻空肠置管肠内低脂营养预防白血病患儿门冬酰胺酶相关性胰腺炎(AAP)的临床经验,为临床用药提供依据。方法 2013年11月-2016年5月,我院8例ALL患儿在诱导缓解期并发AAP,于延迟强化期再次应用包含门冬酰胺酶的联合化疗,予以奥曲肽联合鼻空肠置管肠内低脂营养。统计该组患儿在延迟强化期胰腺炎的发生情况。结果 8例患儿均再无APP及门冬酰胺酶其他相关并发症发生。结论应用奥曲肽联合鼻空肠置管肠内低脂营养,门冬酰胺酶再暴露时相关并发症的发生明显减少。Objective The experiences of octreotide combined with nasojejunal catheterization and enteral low-fat nutrition in the prevention of asparaginase-associated pancreatitis(AAP)in children with leukemia were retrospectively summarized and analyzed.Methods Clinical data of 8 children with acute lymphoblastic leukemia(ALL)during delayed enhancement from November 2013 to May 2016 in our hospital were collected.Eight patients were combined with AAP during induction and received octreotide combined with nasojejunal catheterization for enteral low-fat nutrition during delayed enhancement.Patients in this group were treated with asparaginase.The incidence of pancreatitis was counted,and the clinical data were analyzed and summarized.Results No pancreatitis and other asparaginase-related complications occurred in this group.Conclusions Under the premise of octreotide,combined with low-fat nutrition in the intestinal jejunum,the safety of re-exposure to asparaginase is high,and the occurrence of asparaginaserelated complications is significantly reduced,which provides a therapeutic reference for chemotherapy in children with leukemia.

关 键 词：奥曲肽 鼻空肠置管 胰腺炎 儿童 白血病 

分 类 号：R733.7[医药卫生—肿瘤] R725.7[医药卫生—临床医学]